Evidence map›Paper›PMID 29066542›Full record

ArticlemBio2017

Mechanisms of CNS Viral Seeding by HIV

Mike Veenstra, Rosiris León-Rivera, Ming Li, Lucio Gama, Janice E Clements, Joan W Berman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 1 synthesis or guideline pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Epigenetic mechanisms of HIV and opioid-induced neuropathology: Potential therapies and interventions.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  12. Article
  13. EcoHIV Infection Promotes Atherosclerosis Progression in LDLR-Deficient Mice.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  14. Article
  15. Article
  16. HIV-1 latency: From acquaintance to confidant.Journal of virus eradication · 2025
    Review
  17. Review
  18. Article
  19. Article
  20. Single-cell analysis of CD14Frontiers in immunology · 2025
    Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mike VeenstraDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Rosiris León-RiveraDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.
Ming LiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lucio GamaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Janice E ClementsDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Joan W BermanDepartment of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA joan.berman@einstein.yu.edu.
Albert Einstein College of Medicine · USJohns Hopkins University · USJohns Hopkins Medicine · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HARRIS GOLDSTEIN · 2017 to 2026
$28.3M
Mechanisms of HAD:Role of CCL2 BBB & HIV InfectionR01MH075679 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERMAN, JOAN WEINBERGER · 2006 to 2016
$4.0M
Macrophage Ontogeny and Polarization in HIV/SIV InfectionR01AI127142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, GAMA, LUCIO · 2016 to 2020
$3.8M
Novel SIV Model of HANDR01NS077869 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CLEMENTS, JANICE E, MANKOWSKI, JOSEPH L · 2012 to 2016
$3.8M
Monocyte CNS HIV entry & neurodegeneration: Translational studies in the CART eraR01MH112391 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERMAN, JOAN WEINBERGER, MORGELLO, SUSAN · 2017 to 2021
$3.7M
Role of cellular prion protein in the pathogenesis of NeuroAIDSR01MH090958 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERMAN, JOAN WEINBERGER · 2011 to 2015
$1.9M
Clinical and Translational Science AwardTL1TR001072 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$909k
Mechanisms of HIV Tat regulation of macrophage gene expression in neuroAIDSR21MH102113 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERMAN, JOAN WEINBERGER · 2014 to 2015
$459k
NCATS NIH HHS TL1 TR001072NIAID NIH HHS P30 AI124414NIAID NIH HHS R01 AI127142NIGMS NIH HHS T32 GM007288NIMH NIH HHS R01 MH075679NIMH NIH HHS R01 MH090958NIMH NIH HHS R01 MH112391NIMH NIH HHS R21 MH102113NINDS NIH HHS R01 NS077869
6 · The paper itself

Abstract

HIV reservoirs persist despite antiretroviral therapy (ART) and are established within a few days after infection. Infected myeloid cells in the central nervous system (CNS) may contribute to the establishment of a CNS viral reservoir. The mature CD14

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAntigens, CDBlood-Brain BarrierCell Adhesion MoleculesCell Adhesion Molecules, NeuronalCentral Nervous SystemFetal ProteinsGPI-Linked ProteinsHIV InfectionsHumansLipopolysaccharide ReceptorsMonocytesNeurocognitive DisordersReceptors, CCR2Receptors, Cell SurfaceReceptors, IgGActivated-Leukocyte Cell Adhesion MoleculeALCAM protein, humanAntigens, CDCCR2 protein, humanCell Adhesion MoleculesCell Adhesion Molecules, NeuronalF11R protein, humanFCGR3B protein, humanFetal ProteinsGPI-Linked ProteinsLipopolysaccharide ReceptorsReceptors, CCR2Receptors, Cell SurfaceReceptors, IgGCNScognitionHIVqPCRreservoirs

Identifiers

PMID29066542
PMCPMC5654927
OpenAlexW2765432785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.