Evidence map›Paper›PMID 29066444›Full record

Trial reportJournal of the American Heart Association2017

Effect of Monthly, High-Dose, Long-Term Vitamin D Supplementation on Central Blood Pressure Parameters: A Randomized Controlled Trial Substudy.

John D Sluyter, Carlos A Camargo, Alistair W Stewart, Debbie Waayer, Carlene M M Lawes, Les Toop, Kay-Tee Khaw, Simon A McG Thom, Bernhard Hametner, Siegfried Wassertheurer and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Overview of results from the Vitamin D Assessment (ViDA) study.Journal of endocrinological investigation · 2019
    Trial
  11. Trial
  12. Review
  13. Article
  14. Article
  15. Review
  16. Vitamin D and hypertension in the elderly; closer to implementation!American heart journal plus : cardiology research and practice · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

John D SluyterSchool of Population Health, University of Auckland, New Zealand j.sluyter@auckland.ac.nz.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Alistair W StewartSchool of Population Health, University of Auckland, New Zealand.
Debbie WaayerSchool of Population Health, University of Auckland, New Zealand.
Carlene M M LawesSchool of Population Health, University of Auckland, New Zealand.
Les ToopDepartment of General Practice, The University of Otago, Christchurch, New Zealand.
Kay-Tee KhawDepartment of Public Health, University of Cambridge, United Kingdom.
Simon A McG ThomInternational Centre for Circulatory Health, Imperial College London, London, United Kingdom.
Bernhard HametnerCenter for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria.
Siegfried WassertheurerCenter for Health & Bioresources, AIT Austrian Institute of Technology, Vienna, Austria.
Kim H ParkerDepartment of Bioengineering, Imperial College London, London, United Kingdom.
Alun D HughesInstitute of Cardiovascular Sciences, University College London, London, United Kingdom.
Robert ScraggSchool of Population Health, University of Auckland, New Zealand.

Funding

Medical Research Council G1000143
6 · The paper itself

Abstract

backgroundThe effects of monthly, high-dose, long-term (≥1-year) vitamin D supplementation on central blood pressure (BP) parameters are unknown. METHODS AND

resultsA total of 517 adults (58% male, aged 50-84 years) were recruited into a double-blinded, placebo-controlled trial substudy and randomized to receive, for 1.1 years (median; range: 0.9-1.5 years), either (1) vitamin D

conclusionsMonthly, high-dose, 1-year vitamin D supplementation lowered central BP parameters among adults with vitamin D deficiency but not in the total sample. CLINICAL

trial registrationURL: http://www.anzctr.org.au. Unique identifier: ACTRN12611000402943.

Indexed as

Dietary SupplementsAgedAged, 80 and overAntihypertensive AgentsBiomarkersBlood PressureBrachial ArteryCholecalciferolDouble-Blind MethodDrug Administration ScheduleFemaleHumansHypertensionIntention to Treat AnalysisMaleMiddle Aged25-hydroxyvitamin DAntihypertensive AgentsBiomarkersCholecalciferolVitamin Darterial stiffnessblood pressurerandomized controlled trialvitamin Dwave reflection

Identifiers

PMID29066444
PMCPMC5721873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.