Evidence map›Paper›PMID 29066292›Full record

ArticleMolecular and cellular neurosciences2017

Rem2 signaling affects neuronal structure and function in part by regulation of gene expression.

Katelyn Kenny, Leandro Royer, Anna R Moore, Xiao Chen, Michael T Marr, Suzanne Paradis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular neurosciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Experience-Dependent Development of Dendritic Arbors in Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katelyn KennyDepartment of Biology, Brandeis University, Waltham, MA 02454, United States.
Leandro RoyerDepartment of Biology, Brandeis University, Waltham, MA 02454, United States.
Anna R MooreDepartment of Biology, Brandeis University, Waltham, MA 02454, United States; Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, United States; National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, United States.
Xiao ChenDepartment of Biology, Brandeis University, Waltham, MA 02454, United States; National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, United States.
Michael T MarrDepartment of Biology, Brandeis University, Waltham, MA 02454, United States; Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02454, United States.
Suzanne ParadisDepartment of Biology, Brandeis University, Waltham, MA 02454, United States; Volen Center for Complex Systems, Brandeis University, Waltham, MA 02454, United States; National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02454, United States. Electronic address: paradis@brandeis.edu.
Brandeis University · US

Funding

Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
Semaphorin-Dependent GABAergic Synapse Formation: A Novel Approach to Increasing Inhibition in the Intact BrainR01NS065856 · NINDS · BRANDEIS UNIVERSITY · PI PARADIS, SUZANNE · 2010 to 2024
$5.4M
FOXO Regulon and Translation ControlR01GM117034 · NIGMS · BRANDEIS UNIVERSITY · PI MARR, MICHAEL THOMAS · 2016 to 2019
$1.3M
Molecular mechanisms of activity-dependent changes in neuronal connectivityK01MH101639 · NIMH · BRANDEIS UNIVERSITY · PI MOORE, ANNA R · 2014 to 2016
$288k
NIGMS NIH HHS R01 GM117034NIMH NIH HHS K01 MH101639NINDS NIH HHS R01 NS065856NINDS NIH HHS T32 NS007292
6 · The paper itself

Abstract

The central nervous system has the remarkable ability to convert changes in the environment in the form of sensory experience into long-term alterations in synaptic connections and dendritic arborization, in part through changes in gene expression. Surprisingly, the molecular mechanisms that translate neuronal activity into changes in neuronal connectivity and morphology remain elusive. Rem2, a member of the Rad/Rem/Rem2/Gem/Kir (RGK) subfamily of small Ras-like GTPases, is a positive regulator of synapse formation and negative regulator of dendritic arborization. Here we identify that one output of Rem2 signaling is the regulation of gene expression. Specifically, we demonstrate that Rem2 signaling modulates the expression of genes required for a variety of cellular processes from neurite extension to synapse formation and synaptic function. Our results highlight Rem2 as a unique molecule that transduces changes in neuronal activity detected at the cell membrane to morphologically relevant changes in gene expression in the nucleus.

Indexed as

AnimalsBrainCells, CulturedGene Expression RegulationGene Knockout TechniquesMiceMonomeric GTP-Binding ProteinsNeurogenesisNeuronsSignal TransductionMonomeric GTP-Binding ProteinsRem2 protein, mouseActivity-regulatedExcitatory synapseGlypican-5 (Gpc5)Lrrtm4Rem2

Identifiers

PMID29066292
PMCPMC5781234
OpenAlexW2766516551

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.