Evidence map›Paper›PMID 29066284›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2018

Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca

Miao Liu, Amanda Hoskins, Nirmal Verma, Donald M Bers, Sanda Despa, Florin Despa

Open access · greenAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Miao LiuDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
Amanda HoskinsDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
Nirmal VermaDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, CA 95616, USA.
Sanda DespaDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
Florin DespaDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA. Electronic address: f.despa@uky.edu.
University of Kentucky · USUniversity of California, Davis · US

Funding

Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
Programming amylin secretion to slow brain aging - an animal modelR01AG057290 · NIA · UNIVERSITY OF KENTUCKY · PI DESPA, FLORIN, THINAKARAN, GOPAL · 2017 to 2021
$3.3M
Role of Systemic Amylin Dyshomeostasis in Alzheimer's DiseaseR01AG053999 · NIA · UNIVERSITY OF KENTUCKY · PI DESPA, FLORIN · 2016 to 2020
$1.9M
Role of myocyte Na+ dysregulation in diabetic heart diseaseR01HL135000 · NHLBI · UNIVERSITY OF KENTUCKY · PI DESPA, SANDA · 2017 to 2020
$1.7M
Hyperamylinemia in Diabetic Heart Disease: Mechanisms, Responses, and PreventionR01HL118474 · NHLBI · UNIVERSITY OF KENTUCKY · PI DESPA, FLORIN · 2013 to 2016
$1.5M
NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL118474NHLBI NIH HHS R01 HL135000NIA NIH HHS R01 AG053999NIA NIH HHS R01 AG057290
6 · The paper itself

Abstract

Amylin is a pancreatic β-cell hormone co-secreted with insulin, plays a role in normal glucose homeostasis, and forms amyloid in the pancreatic islets of individuals with type-2 diabetes. Aggregated amylin is also found in blood and extra-pancreatic tissues, including myocardium. Myocardial amylin accumulation is associated with myocyte Ca

Indexed as

Calcium SignalingVentricular RemodelingAnimalsCalciumDiabetic CardiomyopathiesDisease Models, AnimalFemaleInflammation MediatorsInfusions, IntravenousInterleukin-1betaIslet Amyloid PolypeptideMaleMice, KnockoutMyocytes, CardiacProtein AggregatesProtein Aggregation, PathologicalCalciumIL1B protein, mouseInflammation MediatorsInterleukin-1betaIslet Amyloid PolypeptideProtein AggregatesAmylinCalciumDiabetic cardiomyopathyHyperamylinemiaPrediabetesType-2 diabetes

Identifiers

PMID29066284
PMCPMC5889317
OpenAlexW2766669176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.