Evidence map›Paper›PMID 29066221›Full record

ArticleJournal of autoimmunity2018

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint.

Louisa E Jeffery, Peter Henley, Nefisa Marium, Andrew Filer, David M Sansom, Martin Hewison, Karim Raza

Open access · hybridAbstract read
In one paragraph

Article in Journal of autoimmunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Effects of vitamin D supplements on frequency of CD4European journal of clinical nutrition · 2019
    Trial
  3. Vitamin D and Endometriosis: Is There a Mechanistic Link?Cell biochemistry and function · 2025
    Review
  4. Review
  5. Immunosenescence of T cells: a key player in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
  15. Review
  16. Article
  17. Vitamin D, Autoimmune Disease and Rheumatoid Arthritis.Calcified tissue international · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Louisa E JefferyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
Peter HenleyInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
Nefisa MariumInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK.
Andrew FilerInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2WB, UK.
David M SansomUCL Institute of Immunity and Transplantation, University College London UK.
Martin HewisonInstitute of Metabolism and Systems Research, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, B15 2TT, UK. Electronic address: m.hewison@bham.ac.uk.
Karim RazaInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK; Department of Rheumatology, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
University of Birmingham · GBSandwell & West Birmingham Hospitals NHS Trust · GBUniversity College London · GBUniversity Hospitals Birmingham NHS Foundation Trust · GB

Funding

DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
Arthritis Research UK 20298NIAMS NIH HHS R01 AR063910Versus Arthritis 19364Wellcome Trust
6 · The paper itself

Abstract

1,25-dihydroxyvitaminD

Indexed as

AdultAgedAged, 80 and overArthritis, RheumatoidCalcitriolCells, CulturedFemaleHumansImmunologic MemoryImmunosuppressive AgentsInterferon-gammaInterleukin-17JointsMaleMiddle AgedSynovial FluidCalcitriolImmunosuppressive AgentsInterferon-gammaInterleukin-17Peripheral bloodRheumatoid arthritisSynovial fluidT cellVitamin DVitamin D receptor

Identifiers

PMID29066221
PMCPMC5854374
OpenAlexW2765618185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.