Observational studyArthritis research & therapy2017
Relevance of structural damage in the sacroiliac joints for the functional status and spinal mobility in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort.
Observational study in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01277419 (German Spondyloarthritis Inception Cohort), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
German Spondyloarthritis Inception Cohort
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- [Long version on the S3 guidelines for axial spondyloarthritis including Bechterew's disease and early forms, Update 2019 : Evidence-based guidelines of the German Society for Rheumatology (DGRh) and participating medical scientific specialist societies and other organizations].Zeitschrift fur Rheumatologie · 2019Guideline
- Assessment of sacroiliitis using zero echo time magnetic resonance imaging: a comprehensive evaluation.Pediatric radiology · 2025Article
- Global Functioning in Axial Spondyloarthritis is Stronger Associated With Disease Activity and Function Than With Mobility and Radiographic Damage.Arthritis care & research · 2025Article
- Distribution of spinal damage in patients with axial spondyloarthritis as assessed by MRI: a prospective and blinded study.Arthritis research & therapy · 2025Article
- Sacroiliac and spine imaging in spondyloarthritis: Does phenotype or sex matter?Advances in rheumatology (London, England) · 2024Article
- Sensitivity to change of structural outcomes in axial spondyloarthritis after 10 years of follow up. Data from the DESIR cohort.RMD open · 2024Article
- Navigating the Factors Affecting Functional Impairment in Spondyloarthritis.Sultan Qaboos University medical journal · 2024Article
- Analysis of ASAS health index and its influencing factors in ankylosing spondylitis: a prospective study based on the population of Chaoshan region.Frontiers in medicine · 2024Article
- Impact of daily physical therapy over 2 weeks on spinal mobility including objective electronic measurements and function in patients with axial spondyloarthritis.Therapeutic advances in musculoskeletal disease · 2024Article
- Physical function and sex differences in radiographic axial spondyloarthritis: a cross-sectional analysis on Bath Ankylosing Spondylitis Functional Index.Arthritis research & therapy · 2023Observational
- Article
- High prevalence of sacroiliitis and early structural changes in the sacroiliac joint in children with enthesitis-related arthritis: findings from a tertiary centre in Hong Kong.Pediatric rheumatology online journal · 2023Article
- High Usability and Applicability Ratings for the New SmartClicRheumatology and therapy · 2023Article
- Disease course of non-radiographic axial spondyloarthritis: Data from a long-term retrospective observational cohort.PloS one · 2023Observational
- Article
- Distribution of Acute and Chronic Lesions in the Sacroiliac Joints of Patients with Axial Spondyloarthritis.International journal of general medicine · 2022Article
- Reactive arthritis after COVID-19: a case-based review.Rheumatology international · 2021Review
- Treat-to-target in axial spondyloarthritis - what about physical function and activity?Nature reviews. Rheumatology · 2021Review
- Relationship between spinal structural damage on radiography and bone fragility on CT in ankylosing spondylitis patients.Scientific reports · 2021Article
- Understanding the paradigm of non-radiographic axial spondyloarthritis.Clinical rheumatology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional status and spinal mobility in patients with axial spondyloarthritis (axSpA) are known to be determined both by disease activity and by structural damage in the spine. The impact of structural damage in the sacroiliac joints (SIJ) on physical function and spinal mobility in axSpA has not been studied so far. The objective of the study was to analyze the impact of radiographic sacroiliitis on functional status and spinal mobility in patients with axSpA.
methodsIn total, 210 patients with axSpA were included in the analysis. Radiographs of SIJ obtained at baseline and after 2 years of follow up were scored by two trained readers according to the modified New York criteria grading system (grade 0-4). The mean of two readers' scores for each joint and a sum score for both SIJ were calculated for each patient giving a sacroiliitis sum score between 0 and 8. The Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Metrology Index (BASMI) at baseline and after 2 years were used as outcome measures.
resultsLongitudinal mixed model analysis adjusted for structural damage in the spine (modified Stoke Ankylosing Spondylitis Spine Score - mSASSS), disease activity (Bath Ankylosing Spondylitis Disease Activity Index - BASDAI and C-reactive protein level) and gender, revealed an independent association of the sacroiliitis sum score with the BASFI: b = 0.10 (95% CI 0.01-0.19) and the BASMI: b = 0.12 (95% CI 0.03-0.21), respectively, indicating that change by one radiographic sacroiliitis grade in one joint is associated with BASFI/BASMI worsening by 0.10/0.12 points, respectively, independently of disease activity and structural damage in the spine.
conclusionStructural damage in the SIJ might have an impact on functional status and spinal mobility in axSpA independently of spinal structural damage and disease activity.
trial registrationClinicalTrials.gov, NCT01277419 . Registered on 14 January 2011.
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