ArticleArthritis research & therapy2017
Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intra-articular magnesium to alleviate postoperative pain after arthroscopic knee surgery: a meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2021Pooled it
- The relationship between magnesium and osteoarthritis of knee: A MOOSE guided systematic review and meta-analysis.Medicine · 2019Pooled it
- Diuretic-Induced Hypomagnesemia May Play a Key Role in the Development of Calcium Pyrophosphate Arthritis.Rheumatology and therapy · 2026Article
- Associations between hyperuricemia and ultrasound-detected knee synovial abnormalities in middle-aged and older population: a cross-sectional study.Journal of orthopaedic surgery and research · 2024Article
- Association between hyperuricaemia and hand osteoarthritis: data from the Xiangya Osteoarthritis Study.RMD open · 2023Observational
- Increased Wnt/β-catenin signaling contributes to autophagy inhibition resulting from a dietary magnesium deficiency in injury-induced osteoarthritis.Arthritis research & therapy · 2022Article
- Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.Osteoarthritis and cartilage · 2022Article
- A Cross-Sectional Study of Association between Plasma Selenium Levels and the Prevalence of Osteoarthritis: Data from the Xiangya Osteoarthritis Study.The journal of nutrition, health & aging · 2022Article
- Research status of biodegradable metals designed for oral and maxillofacial applications: A review.Bioactive materials · 2021Review
- Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study.Arthritis & rheumatology (Hoboken, N.J.) · 2021Article
- Prevalence of ultrasound-detected knee synovial abnormalities in a middle-aged and older general population-the Xiangya Osteoarthritis Study.Arthritis research & therapy · 2021Article
- Associations of serum iron and ferritin with hyperuricemia and serum uric acid.Clinical rheumatology · 2020Article
- Physical Distancing Measures and Walking Activity in Middle-aged and Older Residents in Changsha, China, During the COVID-19 Epidemic Period: Longitudinal Observational Study.Journal of medical Internet research · 2020Observational
- Association between serum zinc and copper concentrations and copper/zinc ratio with the prevalence of knee chondrocalcinosis: a cross-sectional study.BMC musculoskeletal disorders · 2020Article
- Association between dietary selenium intake and the prevalence of osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2019Article
- [Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?]Der Orthopade · 2019Review
- Association between dietary iron intake and the prevalence of nonalcoholic fatty liver disease: A cross-sectional study.Medicine · 2019Article
- Dose-response relationship between higher serum calcium level and higher prevalence of hyperuricemia: A cross-sectional study.Medicine · 2019Observational
- Article
- Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition.Arthritis & rheumatology (Hoboken, N.J.) · 2018Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundThe aim was to assess serum magnesium levels in relation to prevalence of knee chondrocalcinosis in two population-based Chinese studies.
methodsData included in this analysis consisted of two population-based cross-sectional studies, i.e., the Xiangya Hospital Health Management Center Study and the Xiangya Osteoarthritis (XO) Study I. A bilateral knee anteroposterior radiograph was obtained from each subject. Radiographic knee chondrocalcinosis was present if there was definite linear cartilage calcification. Serum magnesium concentration was measured using the chemiluminescence method. We examined the relation of serum magnesium levels to prevalence of knee chondrocalcinosis using generalized estimating equations.
resultsThe prevalence of knee chondrocalcinosis was 1.4% in the Xiangya Hospital Health Management Center Study (n = 12,631). Compared with the lowest tertile, the age, sex and body mass index (BMI)-adjusted odds ratios (ORs) of chondrocalcinosis were 0.59 (95% CI 0.40-0.87) and 0.49 (95% CI 0.33-0.72) in the second and the third tertiles of serum magnesium, respectively (P for trend <0.001). The prevalence of knee chondrocalcinosis in the XO Study I (n = 1316) was 4.1%. The age, sex and BMI-adjusted ORs of chondrocalcinosis were 0.67 (95% CI 0.34-1.30) in the second and 0.45 (95% CI 0.21-0.94) in the third tertile of serum magnesium when compared with the lowest tertile (P for trend = 0.030). Similar results were observed in men and women in both studies. Adjusting for additional potential confounders did not change the results materially.
conclusionsSubjects with lower levels of serum magnesium, even within the normal range, had higher prevalence of knee chondrocalcinosis in a dose-response relationship manner, suggesting that magnesium may have a preventive or therapeutic potential for knee chondrocalcinosis.
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