Evidence map›Paper›PMID 29065884›Full record

ArticleMalaria journal2017

Risk factors and pregnancy outcomes associated with placental malaria in a prospective cohort of Papua New Guinean women.

Elvin Lufele, Alexandra Umbers, Jaume Ordi, Maria Ome-Kaius, Regina Wangnapi, Holger Unger, Nandao Tarongka, Peter Siba, Ivo Mueller, Leanne Robinson and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
5.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  16. Current update on malaria in pregnancy: a systematic review.Tropical diseases, travel medicine and vaccines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Elvin LufelePapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Alexandra UmbersPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Jaume OrdiBarcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Maria Ome-KaiusPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Regina WangnapiPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Holger UngerPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Nandao TarongkaPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Peter SibaPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Ivo MuellerPopulation Health and Immunity Division, Walter and Eliza Hall Institute, Melbourne, VIC, Australia.
Leanne RobinsonPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Stephen RogersonDepartment of Medicine and Radiology, Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia. sroger@unimelb.edu.au.ORCID 0000-0003-4287-1982
Papua New Guinea Institute of Medical Research · PGThe University of Melbourne · AUBarcelona Centre for International Affairs · ESBurnet Institute · AUInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlasmodium falciparum in pregnancy results in substantial poor health outcomes for both mother and child, particularly in young, primigravid mothers who are at greatest risk of placental malaria (PM) infection. Complications of PM include maternal anaemia, low birth weight and preterm delivery, which contribute to maternal and infant morbidity and mortality in coastal Papua New Guinea (PNG).

methodsPlacental biopsies were examined from 1451 pregnant women who were enrolled in a malaria prevention study at 14-26 weeks gestation. Clinical and demographic information were collected at first antenatal clinic visits and women were followed until delivery. Placental biopsies were collected and examined for PM using histology. The presence of infected erythrocytes and/or the malaria pigment in monocytes or fibrin was used to determine the type of placental infection.

resultsOf 1451 placentas examined, PM infection was detected in 269 (18.5%), of which 54 (3.7%) were acute, 55 (3.8%) chronic, and 160 (11.0%) were past infections. Risk factors for PM included residing in rural areas (adjusted odds ratio (AOR) 3.65, 95% CI 1.76-7.51; p ≤ 0.001), being primigravid (AOR 2.45, 95% CI 1.26-4.77; p = 0.008) and having symptomatic malaria during pregnancy (AOR 2.05, 95% CI 1.16-3.62; p = 0.013). After adjustment for covariates, compared to uninfected women, acute infections (AOR 1.97, 95% CI 0.98-3.95; p = 0.056) were associated with low birth weight babies, whereas chronic infections were associated with preterm delivery (AOR 3.92, 95% CI 1.64-9.38; p = 0.002) and anaemia (AOR 2.22, 95% CI 1.02-4.84; p = 0.045).

conclusionsAmong pregnant PNG women receiving at least one dose of intermittent preventive treatment in pregnancy and using insecticide-treated bed nets, active PM infections were associated with adverse outcomes. Improved malaria prevention is required to optimize pregnancy outcomes.

Indexed as

AdolescentAdultAnemiaAntimalarialsFemaleHumansInsecticide-Treated BednetsMalaria, FalciparumMiddle AgedPapua New GuineaPlacentaPregnancyPregnancy Complications, ParasiticPregnancy OutcomeProspective StudiesRisk FactorsAntimalarialsBirth outcomesInsecticide-treated bed netsIntermittent preventive treatment in pregnancyPapua New GuineaPlacental malariaPregnancy

Identifiers

PMID29065884
PMCPMC5655867
OpenAlexW2766114312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.