ArticleJournal of neurotrauma2018
Acute White-Matter Abnormalities in Sports-Related Concussion: A Diffusion Tensor Imaging Study from the NCAA-DoD CARE Consortium.
Article in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Characteristic patterns of white matter tract injury in sport-related concussion: An image based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- The second decade of DTI in TBI part 1: a systematic review of mild TBI.Frontiers in neurologyPooled it
- Mechanical deformation explains distinct neuroimaging patterns and etiologies in brain trauma.NeuroImage · 2026Article
- Reduced cortical excitability is associated with head impact severity and cognitive symptoms in adolescent football players.iScience · 2026Article
- Association of Alzheimer's Disease Polygenic Risk Score with Concussion Severity and Recovery Metrics.Sports medicine (Auckland, N.Z.) · 2025Article
- Efficacy of biomarkers and imaging techniques for the diagnosis of traumatic brain injury: challenges and opportunities.Molecular and cellular biochemistry · 2025Review
- Clinical utility of diffusion tensor imaging in sport-related concussion: a systematic review.BJR open · 2025Article
- Quantified Head-Ball Impacts in Soccer: A Preliminary, Prospective Study.Neurotrauma reports · 2025Article
- Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players.medRxiv : the preprint server for health sciences · 2024Article
- Widespread White Matter Abnormalities in Concussed Athletes Detected by 7T Diffusion Magnetic Resonance Imaging.Journal of neurotrauma · 2024Article
- Association of Vascular Risk Factors and CSF and Imaging Biomarkers With White Matter Hyperintensities in Former American Football Players.Neurology · 2024Article
- Biclustering Multivariate Longitudinal Data with Application to Recovery Trajectories of White Matter After Sport-Related Concussion.Data science in science · 2024Article
- Longitudinal Associations Between Blood Biomarkers and White Matter MRI in Sport-Related Concussion: A Study of the NCAA-DoD CARE Consortium.Neurology · 2023Article
- The consideration of post-exercise impact on SCAT3 scores in athletes immediately following a head injury.Brain injury · 2023Article
- Characteristics and Outcomes of Athletes With Slow Recovery From Sports-Related Concussion: A CARE Consortium Study.Neurology · 2023Observational
- Concussions in young adult athletes: No effect on cerebral white matter.Frontiers in human neuroscience · 2023Article
- Effects of White-Matter Tract Length in Sport-Related Concussion: A Tractography Study from the NCAA-DoD CARE Consortium.Journal of neurotrauma · 2022Article
- MEG measured delta waves increase in adolescents after concussion.Brain and behavior · 2022Article
- Longitudinal white matter microstructural changes in pediatric mild traumatic brain injury: An A-CAP study.Human brain mapping · 2022Article
- Repeated Mild TBI in Adolescent Rats Reveals Sex Differences in Acute and Chronic Behavioral Deficits.Neuroscience · 2022Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 1 country.
Funding
Abstract
Sports-related concussion (SRC) is an important public health issue. Although standardized assessment tools are useful in the clinical management of acute concussion, the underlying pathophysiology of SRC and the time course of physiological recovery after injury remain unclear. In this study, we used diffusion tensor imaging (DTI) to detect white matter alterations in football players within 48 h after SRC. As part of the NCAA-DoD CARE Consortium study of SRC, 30 American football players diagnosed with acute concussion and 28 matched controls received clinical assessments and underwent advanced magnetic resonance imaging scans. To avoid selection bias and partial volume effects, whole-brain skeletonized white matter was examined by tract-based spatial statistics to investigate between-group differences in DTI metrics and their associations with clinical outcome measures. Mean diffusivity was significantly higher in brain white matter of concussed athletes, particularly in frontal and subfrontal long white matter tracts. In the concussed group, axial diffusivity was significantly correlated with the Brief Symptom Inventory and there was a similar trend with the symptom severity score of the Sport Concussion Assessment Tool. In addition, concussed athletes with higher fractional anisotropy performed better on the cognitive component of the Standardized Assessment of Concussion. Overall, the results of this study are consistent with the hypothesis that SRC is associated with changes in white matter tracts shortly after injury, and these differences are correlated clinically with acute symptoms and functional impairments.
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