ArticleTissue engineering. Part A2018
Phosphate Functional Groups Improve Oligo[(Polyethylene Glycol) Fumarate] Osteoconduction and BMP-2 Osteoinductive Efficacy.
Article in Tissue engineering. Part A, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Advances in 3D bioprinting to enhance translational applications in bone tissue engineering and regenerative medicine.Histology and histopathology · 2025Review
- Design, Synthesis and Actual Applications of the Polymers Containing Acidic P-OH Fragments: Part 2-Sidechain Phosphorus-Containing Polyacids.International journal of molecular sciences · 2023Review
- Injectable pH-responsive adhesive hydrogels for bone tissue engineering inspired by the underwater attachment strategy of marine mussels.Biomaterials advances · 2022Article
- Black phosphorus incorporation modulates nanocomposite hydrogel properties and subsequent MC3T3 cell attachment, proliferation, and differentiation.Journal of biomedical materials research. Part A · 2021Article
- 2D phosphorene nanosheets, quantum dots, nanoribbons: synthesis and biomedical applications.Biomaterials science · 2021Review
- Effect of inorganic phosphate on migration and osteogenic differentiation of bone marrow mesenchymal stem cells.BMC developmental biology · 2021Article
- SDF-1Stem cells international · 2021Article
- 3D bioprinting of oligo(poly[ethylene glycol] fumarate) for bone and nerve tissue engineering.Journal of biomedical materials research. Part A · 2021Article
- BMP and TGFβ use and release in bone regenerationTurkish journal of medical sciences · 2020Review
- Phosphate functionalization and enzymatic calcium mineralization synergistically enhance oligo[poly(ethylene glycol) fumarate] hydrogel osteoconductivity for bone tissue engineering.Journal of biomedical materials research. Part A · 2020Article
- Advancements in Hydrogel-Based Drug Sustained Release Systems for Bone Tissue Engineering.Frontiers in pharmacology · 2020Review
- The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent.Tissue engineering. Part A · 2019Article
- In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles.Tissue engineering. Part C, Methods · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Off-the-shelf availability in large quantities, drug delivery functionality, and modifiable chemistry and mechanical properties make synthetic polymers highly suitable candidates for bone grafting. However, most synthetic polymers lack the ability to support cell attachment, proliferation, migration, and differentiation, and ultimately tissue formation. Incorporating anionic peptides into the polymer that mimics acidic proteins, which contribute to biomineralization and cellular attachment, could enhance bone formation. Therefore, this study investigates the effect of a phosphate functional group on osteoconductivity and BMP-2-induced bone formation in an injectable and biodegradable oligo[(polyethylene glycol) fumarate] (OPF) hydrogel. Three types of OPF hydrogels were fabricated using 0%, 20%, or 40% Bis(2-(methacryloyloxy)ethyl) phosphate creating unmodified OPF-noBP and phosphate-modified OPF-BP20 and OPF-BP40, respectively. To account for the osteoinductive effect of various BMP-2 release profiles, two different release profiles (i.e., different ratios of burst and sustained release) were obtained by varying the BMP-2 loading method. To investigate the osteoconductive effect of phosphate modification, unloaded OPF composites were assessed for bone formation in a bone defect model after 3, 6, and 9 weeks. To determine the effect of the hydrogel phosphate modification on BMP-2-induced bone formation, BMP-2 loaded OPF composites with differential BMP-2 release were analyzed after 9 weeks of subcutaneous implantation in rats. The phosphate-modified OPF hydrogels (OPF-BP20 and OPF-BP40) generated significantly more bone in an orthotopic defect compared to the unmodified hydrogel (OPF-noBP). Furthermore, the phosphate functionalized surface-enhanced BMP-2-induced ectopic bone formation regardless of the BMP-2 release profile. In conclusion, this study clearly shows that phosphate functional groups improve the osteoconductive properties of OPF and enhanced BMP-2-induced bone formation. Therefore, functionalizing hydrogels with phosphate groups by crosslinking monomers into the hydrogel matrix could provide a valuable method for improving polymer characteristics and holds great promise for bone tissue engineering.
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