ArticleAntioxidants & redox signaling2018
Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.
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Article in Antioxidants & redox signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
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Who cites it
32 citing papers in PubMed, 52 citations in OpenAlex.
- Clarifying the molecular mechanisms underlying the lethal in vitro cellular effects and mild organismal phenotype of SOD1 loss.Scientific reports · 2026Article
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- Episodic denervation as a driver of loss of skeletal muscle redox homeostasis and muscle weakness in sarcopenia: Possible amelioration by exercise.Sports medicine and health science · 2025Review
- Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025Review
- Mammalian copper homeostasis: physiological roles and molecular mechanisms.Physiological reviews · 2025Review
- Interplay between Protein Kinase C Epsilon and Reactive Oxygen Species during Myogenic Differentiation.Cells · 2023Article
- Deletion ofeNeuro · 2023Article
- Endogenous and Exogenous Antioxidants in Skeletal Muscle Fatigue Development during Exercise.Antioxidants (Basel, Switzerland) · 2023Review
- Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation.Science advances · 2022Article
- From the Bench to the Bedside: Branched Amino Acid and Micronutrient Strategies to Improve Mitochondrial Dysfunction Leading to Sarcopenia.Nutrients · 2022Review
- A Single Transcript Knockdown-Replacement Strategy Employing 5' UTR Secondary Structures to Precisely Titrate Rescue Protein Translation.Frontiers in genome editing · 2022Article
- Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Redox Signaling and Sarcopenia: Searching for the Primary Suspect.International journal of molecular sciences · 2021Review
- The ketogenic diet preserves skeletal muscle with aging in mice.Aging cell · 2021Article
- Cancer cachexia in a mouse model of oxidative stress.Journal of cachexia, sarcopenia and muscle · 2020Article
- On the mechanisms underlying attenuated redox responses to exercise in older individuals: A hypothesis.Free radical biology & medicine · 2020Article
- Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems.GeroScience · 2020Article
- Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Molecular changes in transcription and metabolic pathways underlying muscle atrophy in the CuZnSOD null mouse model of sarcopenia.GeroScience · 2020Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Giorgos K Sakellariou1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Brian McDonagh1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Helen Porter1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Ifigeneia I Giakoumaki1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Kate E Earl1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Gareth A Nye1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Aphrodite Vasilaki1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Susan V Brooks2 Department of Molecular and Integrative Physiology, University of Michigan , Ann Arbor, Michigan.
Arlan Richardson3 Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center and Oklahoma City VA Medical Center , Oklahoma City, Oklahoma.
Holly Van Remmen4 Oklahoma VA Medical Center , Oklahoma City, Oklahoma.
Anne McArdle1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
Malcolm J Jackson1 MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool , Liverpool, United Kingdom .
University of Liverpool · GBOklahoma Medical Research Foundation · USUniversity of Michigan · USUniversity of Oklahoma Medical Center · US
Funding
PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9MTesting the mechanisms by which NMJ disruption contributes to sarcopeniaI01BX002595 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI VAN REMMEN, HOLLY · 2015 to 2017
–BLRD VA I01 BX002595Medical Research Council G1002120Medical Research Council MR/M012573/1Medical Research Council MR/P003044/1Medical Research Council MR/P020941/1NIA NIH HHS P01 AG051442
Abstract
aimsLack of Cu,Zn-superoxide dismutase (CuZnSOD) in homozygous knockout mice (Sod1
resultsIn contrast to mSod1KO mice, myofiber atrophy in Sod1
Indexed as
AgingAnimalsHumansMiceMice, KnockoutMotor NeuronsMuscle, SkeletalNerve DegenerationNeuromuscular JunctionNeuronsOxidation-ReductionOxidative StressPeroxiredoxin VIProteomicsSarcopeniaSignal TransductionPeroxiredoxin VIPrdx6 protein, mouseSod1 protein, mouseSuperoxide Dismutase-120S proteasomemitochondriamyelinperoxiredoxins 5 and 6superoxide
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.