Evidence map›Paper›PMID 29065681›Full record

ArticleAnalytical chemistry2017

Direct Analysis of Biofluids by Mass Spectrometry with Microfluidic Voltage-Assisted Liquid Desorption Electrospray Ionization.

Xiangtang Li, Rui Xu, Xin Wei, Hankun Hu, Shulin Zhao, Yi-Ming Liu

Abstract read
In one paragraph

Article in Analytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cell Analysis on Microfluidics Combined with Mass Spectrometry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2021
    Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiangtang LiDepartment of Chemistry and Biochemistry, Jackson State University , Jackson, Mississippi 39217, United States.
Rui XuDepartment of Chemistry and Biochemistry, Jackson State University , Jackson, Mississippi 39217, United States.
Xin WeiZhongnan Hospital of Wuhan University , Wuhan 430071, China.
Hankun HuZhongnan Hospital of Wuhan University , Wuhan 430071, China.
Shulin ZhaoState Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University , Guilin 541004, China.ORCID 0000-0002-2560-042X
Yi-Ming LiuDepartment of Chemistry and Biochemistry, Jackson State University , Jackson, Mississippi 39217, United States.ORCID 0000-0002-7760-9565
Jackson State University · USWuhan University · CNGuangxi Normal University · CN

Funding

RCMI-Center for Environmental HealthG12MD007581 · NIMHD · JACKSON STATE UNIVERSITY · PI TCHOUNWOU, PAUL B. · 2012 to 2017
$11.2M
Microfluidic mass spectrometry based fast chemical characterization of exosomesSC1GM089557 · NIGMS · JACKSON STATE UNIVERSITY · PI LIU, YIMING · 2010 to 2018
$1.4M
NIGMS NIH HHS SC1 GM089557NIMHD NIH HHS G12 MD007581
6 · The paper itself

Abstract

Signal suppression by sample matrix in direct electrospray ionization-mass spectrometric (ESI-MS) analysis hampers its clinical and biomedical applications. We report herein the development of a microfluidic voltage-assisted liquid desorption electrospray ionization (VAL-DESI) source to overcome this limitation. Liquid DESI is achieved for the first time in a microfluidic format. Direct analysis of urine, serum, and cell lysate samples by using the proposed microfluidic VAL-DESI-MS/MS method to detect chemical compounds of biomedical interest, including nucleosides, monoamines, amino acids, and peptides is demonstrated. Analyzing a set of urine samples spiked with dihydroxyphenylalanine (DOPA) showed that the assay had a linear calibration curve with r

Indexed as

Microfluidic Analytical TechniquesSpectrometry, Mass, Electrospray IonizationCaffeineErythrocytesHumansMolecular StructureTumor Cells, CulturedCaffeine

Identifiers

PMID29065681
PMCPMC5698120
OpenAlexW2765563691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.