ReviewMaterials (Basel, Switzerland)2017
Activation of Alkaline Irrigation Fluids in Endodontics.
Review in Materials (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Herbal Agents versus Ethylene Diamine Tetra Acetic Acid on Removal of the Smear Layer-A Systematic Review of In Vitro Studies.International journal of environmental research and public health · 2022Pooled it
- The effect of sonic activation of irrigant on postoperative pain after root canal treatment in primary molar teeth: a randomized, clinical study.Clinical oral investigations · 2021Trial
- When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies.Infection · 2025Review
- Article
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Article
- Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy againstJournal of Taibah University Medical Sciences · 2025Review
- An in-vitro study on effects of laser activation on dye penetration in human root dentin.Biomaterial investigations in dentistry · 2024Article
- Influence of 1-Hydroxyethylidene-1,1-Diphosphonic Acid on the Soft Tissue-Dissolving and Gelatinolytic Effect of Ultrasonically Activated Sodium Hypochlorite in Simulated Endodontic Environments.Materials (Basel, Switzerland) · 2021Article
- Antibacterial Effect of Endodontic Disinfections on Enterococcus Faecalis in Dental Root Canals-An In-Vitro Model Study.Materials (Basel, Switzerland) · 2021Article
- Investigating the Antibacterial Effect of Passive Ultrasonic Irrigation, Photodynamic Therapy and Their Combination on Root Canal Disinfection.Journal of lasers in medical sciences · 2021Article
- Novel Approaches to Detect and Treat Biofilms within the Root Canals of Teeth: A Review.Antibiotics (Basel, Switzerland) · 2020Review
- Root canal debridement efficacy of heated sodium hypochlorite in conjunction with passive ultrasonic agitation: An ex vivo study.Journal of dental research, dental clinics, dental prospects · 2020Article
- Evaluation of the evidence of effectiveness of ultrasonic activated irrigation for root canal treatment.Evidence-based dentistry · 2019Article
- Comparative evaluation of pulp tissue dissolution ability of sodium hypochlorite by various activation techniques: AnJournal of conservative dentistry : JCDArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In conventional endodontic treatment, alkaline solutions of sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) are used in combination to disinfect the root canal system and to eliminate debris and smear layers. An important concept that has emerged over recent years is the use of active physical methods for agitating these fluids to improve their penetration within areas that are not reached by endodontic instruments and to accelerate the chemical actions of these alkaline fluids against planktonic microorganisms, biofilms, soft tissue remnants and smear layers. Ultrasonic agitation and more recently pulsed lasers have emerged as two promising methods for activating endodontic irrigation fluids. Ultrasonic agitation with piezoelectric devices employs a moving tip, while laser agitation uses a stationary tip. Both methods cause cavitation, followed by implosions and shear forces which assist with debridement. Fluid streaming further enhances the activity of the fluids. While agitation enhances performance of irrigants, extrusion of fluids from the root canal during activation is a hazard that must be controlled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.