Evidence map›Paper›PMID 29065496›Full record

ReviewFoods (Basel, Switzerland)2017

Curcumin: A Review of Its Effects on Human Health.

Susan J Hewlings, Douglas S Kalman

6 registry-linked trialsAbstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 1,014 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,014citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04269876 naterminatednot on this mapstarted 2019, after this paper: background citation

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Specialized Pro-Resolving Mediator Formulation on Inflammation in Individuals Who Are Overweight to Mildly Obese and Otherwise Generally Healthy

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2019 to 2021Enrolled8ConditionsInflammation, Inflammatory ResponseArmsMarine Lipid Oil Concentrate, Dietary Supplement, Placebo
NCT04654689 phase2completednot on this mapstarted 2021, after this paper: background citation

Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients

TypeinterventionalSponsorFundación Universidad Católica de Valencia San Vicente MártirRan2021 to 2023Enrolled90ConditionsAmyotrophic Lateral SclerosisArmsLiposomed polyphenols resveratrol and curcumin, Placebo for liposomed resveratrol and curcumin, Isocaloric Diet, G04CB02, Placebo microcrystalline methylcellulose
NCT04819646 nacompletednot on this mapstarted 2021, after this paper: background citation

An Open-label, Single-arm Study to Evaluate the Effects of a Marine Lipid Oil Concentrate Formulation on Inflammation/Discomfort in Individuals Who Are Generally Healthy

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2021 to 2021Enrolled31ConditionsInflammationArmsMarine Lipid Oil Concentrate Formulation, Dietary Supplement
NCT05062486 phase2completednot on this mapstarted 2021, after this paper: background citation

An Open-Label, Randomized, Double Arm, Phase 2 Study to Evaluate the Safety and Efficacy of C and RQC for Preventing Progression in Age-Related Macular Degeneration

TypeinterventionalSponsorPaul A Knepper, MD PhDRan2021 to 2024Enrolled55ConditionsAge-related Macular DegenerationArmsResveratrol, Quercetin, Curcumin (RQC), Curcumin
NCT07284316 phase2 / phase3active not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled100ConditionsCognitive Decline, Subjective Cognitive Impairment, Insulin ResistanceArmsTurmeric extract, Control: Placebo. 500mg gelatin in capsules 2 times a day
NCT07436130 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Immunomodulatory Effect of Curcumin in Critically Ill Patients With Sepsis at the Antiguo Hospital Civil de Guadalajara "Fray Antonio Alcalde": A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHospital Civil de GuadalajaraRan2026 to 2027Enrolled56ConditionsSepsisArmsCurcumin, Placebo
3 · Its place in the literature

Who cites it

1,014 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  14. Curcumin enhances the oral bioavailability of testosterone by inhibiting its intestinal metabolism.Drug metabolism and disposition: the biological fate of chemicals · 2025
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  16. Article
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  20. Experimental evaluation ofExperimental and therapeutic medicine · 2026
    Article

954 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Susan J HewlingsDepartment of Nutrition, Central Michigan University Mount Pleasant, MI, USA and Substantiation Sciences Weston, FL 33143, USA. sue.hewlings@gmail.com.ORCID 0000-0001-8540-2591
Douglas S KalmanHealth and Human Performance, Nova Southeastern University and Nutrition Research Division, QPS, Miami, FL 33143, USA. dougkalman@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.

Indexed as

anti-inflammatoryantioxidantcurcuminpolyphenolturmeric

Identifiers

PMID29065496
PMCPMC5664031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.