Evidence map›Paper›PMID 29065472›Full record

ReviewViruses2017

The Battle of RNA Synthesis: Virus versus Host.

Alex Harwig, Robert Landick, Ben Berkhout

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Enzymatic Assays to Explore Viral mRNA Capping Machinery.Chembiochem : a European journal of chemical biology · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. SARS-CoV-2 RNA polymerase as target for antiviral therapy.Journal of translational medicine · 2020
    Article
  16. Article
  17. Article
  18. Review
  19. Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  20. The adaptation of codon usage of +ssRNA viruses to their hosts.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Alex HarwigDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. harwig@wisc.edu.ORCID 0000-0002-1117-9216
Robert LandickDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. landick@bact.wisc.edu.
Ben BerkhoutLaboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands. b.berkhout@amc.uva.nl.
University of Wisconsin–Madison · USAmsterdam UMC Location University of Amsterdam · NL

Funding

STRUCTURE/FUNCTION OF TRANSCRIPTION COMPLEX RNA HAIRPINSR01GM038660 · NIGMS · WASHINGTON UNIVERSITY · PI Robert Landick · 1992 to 2026
$12.2M
Structure/Function of Transcription Complex RNA HairpinsR37GM038660 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI LANDICK, ROBERT · 2001 to 2010
$5.5M
NIGMS NIH HHS R01 GM038660NIGMS NIH HHS R37 GM038660
6 · The paper itself

Abstract

Transcription control is the foundation of gene regulation. Whereas a cell is fully equipped for this task, viruses often depend on the host to supply tools for their transcription program. Over the course of evolution and adaptation, viruses have found diverse ways to optimally exploit cellular host processes such as transcription to their own benefit. Just as cells are increasingly understood to employ nascent RNAs in transcription regulation, recent discoveries are revealing how viruses use nascent RNAs to benefit their own gene expression. In this review, we first outline the two different transcription programs used by viruses, i.e., transcription (DNA-dependent) and RNA-dependent RNA synthesis. Subsequently, we use the distinct stages (initiation, elongation, termination) to describe the latest insights into nascent RNA-mediated regulation in the context of each relevant stage.

Indexed as

Gene Expression Regulation, ViralTranscription, GeneticDNA VirusesHerpesvirus 4, HumanHIV-1Host-Pathogen InteractionsHumansRespiratory Syncytial VirusesRNARNA-Dependent RNA PolymeraseRNA Polymerase IIRNA, ViralViral ProteinsVirusesVirus ReplicationRNARNA-Dependent RNA PolymeraseRNA Polymerase IIRNA, ViralViral ProteinsEpstein-Barr virusHIV-1influenzanascent RNArespiratory syncytial virusRNA-dependent RNA polymeraseRNA polymerase IItranscription

Identifiers

PMID29065472
PMCPMC5691660
OpenAlexW2766023249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.