Evidence map›Paper›PMID 29065458›Full record

ArticleInternational journal of molecular sciences2017

Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models.

Yoshitaka Fujihara, Asami Oji, Tamara Larasati, Kanako Kojima-Kita, Masahito Ikawa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Genetic etiological spectrum of sperm morphological abnormalities.Journal of assisted reproduction and genetics · 2024
    Review
  7. Article
  8. Article
  9. A Human HomozygousGenes · 2024
    Article
  10. PNAS nexus · 2024
    Article
  11. Article
  12. Article
  13. In vivo versus in silico assessment of potentially pathogenic missense variants in human reproductive genes.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Molecular Analysis ofLife (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yoshitaka FujiharaResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. fujihara@biken.osaka-u.ac.jp.
Asami OjiResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. oji-a@cdb.riken.jp.
Tamara LarasatiResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. tamara@biken.osaka-u.ac.jp.
Kanako Kojima-KitaResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. kojima0208@patho.med.osaka-u.ac.jp.
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. ikawa@biken.osaka-u.ac.jp.ORCID 0000-0001-9859-6217
The University of Osaka · JPRIKEN Center for Computational Science · JPThe University of Tokyo · JP

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

A recent genetic analysis of infertile globozoospermic patients identified causative mutations in three genes: a protein interacting with C kinase 1 (

Indexed as

Point MutationAnimalsBase SequenceCRISPR-Cas SystemsDisease Models, AnimalExonsGene EditingHomeodomain ProteinsHomozygoteInfertility, MaleMaleMiceMice, TransgenicSequence DeletionTeratozoospermiaVesicular Transport ProteinsHomeodomain ProteinsSPATA16 protein, humanSpata16 protein, mouseVesicular Transport Proteinsgenome editingmale infertilitymouse modelpoint mutationspermatogenesistestis

Identifiers

PMID29065458
PMCPMC5666888
OpenAlexW2766372106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.