Evidence map›Paper›PMID 29065453›Full record

ReviewPathogens (Basel, Switzerland)2017

An Update on the Sociomicrobiology of Quorum Sensing in Gram-Negative Biofilm Development.

Daniel Passos da Silva, Melissa C Schofield, Matthew R Parsek, Boo Shan Tseng

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 133 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Prevention and Treatment ofPathogens (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Article
  8. Antibacterial and anti-virulence effects ofMicrobiology spectrum · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Daniel Passos da SilvaDepartment of Microbiology, University of Washington School of Medicine, Box 357735, 1959 NE Pacific Street, Seattle, WA 98195-7242, USA. passosds@uw.edu.ORCID 0000-0003-2030-9972
Melissa C SchofieldSchool of Life Sciences, University of Nevada, Las Vegas Box MS 454004 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA. schofi38@unlv.nevada.edu.
Matthew R ParsekDepartment of Microbiology, University of Washington School of Medicine, Box 357735, 1959 NE Pacific Street, Seattle, WA 98195-7242, USA. parsem@u.washington.edu.
Boo Shan TsengSchool of Life Sciences, University of Nevada, Las Vegas Box MS 454004 4505 S. Maryland Parkway, Las Vegas, NV 89154, USA. boo.tseng@unlv.edu.ORCID 0000-0001-7563-0232
University of Nevada, Las Vegas · USUniversity of Washington · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss, Lucas R Hoffman · 2010 to 2026
$21.4M
The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
Pseudomonas biofilms and immunityR01AI097511 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2013 to 2017
$1.9M
Matrix-associated proteins in biofilm tolerance: Psl and ecotinK22AI121097 · NIAID · UNIVERSITY OF NEVADA LAS VEGAS · PI TSENG, BOO SHAN · 2016 to 2017
$268k
NIAID NIH HHS K22 AI121097NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI097511NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

Bacteria are social creatures that are able to interact and coordinate behaviors with each other in a multitude of ways. The study of such group behaviors in microbes was coined "sociomicrobiology" in 2005. Two such group behaviors in bacteria are quorum sensing (QS) and biofilm formation. At a very basic level, QS is the ability to sense bacterial density via cell-to-cell signaling using self-produced signals called autoinducers, and biofilms are aggregates of cells that are attached to one another via a self-produced, extracellular matrix. Since cells in biofilm aggregates are in close proximity, biofilms represent an ecologically relevant environment for QS. While QS is known to affect biofilm formation in both Gram-negative and Gram-positive species, in this review, we will focus exclusively on Gram-negative bacteria, with an emphasis on

Indexed as

biofilmquorum sensingsignalingsociomicrobiology

Identifiers

PMID29065453
PMCPMC5750575
OpenAlexW2767091683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.