Evidence map›Paper›PMID 29064889›Full record

ArticleAnnals of surgery2019

Impact of Sarcopenic Obesity on Outcomes in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma.

Atsushi Kobayashi, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Hisaya Shirai, Siyuan Yao, Naoko Kamo, Shintaro Yagi, Kojiro Taura, Hideaki Okajima and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Annals of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05448222 (Effect of Sarcopenia on the Efficacy and Prognosis of HCC Treated With Systemic Therapies), which is not on this map. Cited by 83 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05448222 unknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of Sarcopenia on the Efficacy and Prognosis of HCC Treated With Systemic Therapies

TypeobservationalSponsorFirst Affiliated Hospital of Wenzhou Medical UniversityRan2022 to 2024Enrolled300ConditionsHepatocellular Carcinoma, SarcopeniaArmsDiagnostic Test: gait speed, ct scan, grip strength and chair stand test
3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 5 syntheses or guidelines pooled it, 167 citations in OpenAlex.

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23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Atsushi KobayashiDivision of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Toshimi Kaido
Yuhei Hamaguchi
Shinya Okumura
Hisaya Shirai
Siyuan Yao
Naoko Kamo
Shintaro Yagi
Kojiro Taura
Hideaki Okajima
Shinji Uemoto
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate preoperative body composition, including skeletal muscle and visceral adipose tissue, and to clarify the impact on outcomes after hepatectomy for hepatocellular carcinoma (HCC).

backgroundRecent studies have indicated that sarcopenia is associated with morbidity and mortality in various pathologies, including cancer, and that obesity or visceral adiposity represents a significant risk factor for several cancers. However, the impact of sarcopenic obesity on outcomes after hepatectomy for HCC has not been fully investigated.

methodsWe retrospectively analyzed 465 patients who underwent primary hepatectomy for HCC between April 2005 and March 2015. Skeletal muscle mass and visceral adipose tissue were evaluated by preoperative computed tomography to define sarcopenia and obesity. Patients were classified into 1 of 4 body composition groups according to the presence or absence of sarcopenia and obesity.

resultsBody composition was classified as nonsarcopenic nonobesity in 184 patients (39%), nonsarcopenic obesity in 219 (47%), sarcopenic nonobesity in 31 (7%), and sarcopenic obesity in 31 (7%). Compared with patients with nonsarcopenic nonobesity, patients with sarcopenic obesity displayed worse median survival (84.7 vs. 39.1 mo, P = 0.002) and worse median recurrence-free survival (21.4 vs. 8.4 mo, P = 0.003). Multivariate analysis identified sarcopenic obesity as a significant risk factor for death (hazard ratio [HR] = 2.504, P = 0.005) and HCC recurrence (HR = 2.031, P = 0.006) after hepatectomy for HCC.

conclusionPreoperative sarcopenic obesity was an independent risk factor for death and HCC recurrence after hepatectomy for HCC.

Indexed as

HepatectomyAdipose TissueAgedBody CompositionCarcinoma, HepatocellularFemaleHumansIntra-Abdominal FatLiver NeoplasmsMaleMuscle, SkeletalObesityPostoperative ComplicationsRetrospective StudiesRisk FactorsSarcopenia

Identifiers

PMID29064889
OpenAlexW2766939863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.