ArticleACS applied materials & interfaces2017
Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry.
Article in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 63 citations in OpenAlex.
- Forward Osmosis for Produced Water Treatment: Comparative Performance Evaluation of Fabricated and Commercial Membranes.Polymers · 2026Article
- Formation and Characterization of Stable Antifouling Colloidal Particles via Surface-Initiated-Photoinduced Electron Transfer-Reversible Addition-Fragmentation Chain-Transfer Polymerization for Standardized Biophysical Measurements.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- The Effective Charge of Low-Fouling Polybetaine Brushes.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- A streamlined proximity extension assay using POEGMA polymer-coated magnetic beads for enhanced protein detection.Frontiers in bioengineering and biotechnology · 2024Article
- Modular Design for Proteins Assembling into Antifouling Coatings: Case of Gold Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Airway mucus in pulmonary diseases: Muco-adhesive and muco-penetrating particles to overcome the airway mucus barriers.International journal of pharmaceutics · 2023Review
- Distinct Antifouling Mechanisms on Different Chain Densities of Zwitterionic Polymers.Molecules (Basel, Switzerland) · 2022Article
- [In-site electrophoretic elution of excessive fluorescein isothiocyanate from fluorescent particles in gel for image analysis].Se pu = Chinese journal of chromatography · 2022Article
- Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.Diagnostics (Basel, Switzerland) · 2021Review
- Facile Impedimetric Analysis of Neuronal Exosome Markers in Parkinson's Disease Diagnostics.Analytical chemistry · 2020Article
- Swelling of Poly(methyl acrylate) Brushes in Acetone Vapor.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- PLL-Poly(HPMA) Bottlebrush-Based Antifouling Coatings: Three Grafting Routes.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Design, Synthesis, and Characterization of Fully Zwitterionic, Functionalized Dendrimers.ACS omega · 2019Article
- Systematic Comparison of Zwitterionic and Non-Zwitterionic Antifouling Polymer Brushes on a Bead-Based Platform.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Romantic Surfaces: A Systematic Overview of Stable, Biospecific, and Antifouling Zwitterionic Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Micron- and nano-sized particles are extensively used in various biomedical applications. However, their performance is often drastically hampered by the nonspecific adsorption of biomolecules, a process called biofouling, which can cause false-positive and false-negative outcomes in diagnostic tests. Although antifouling coatings have been extensively studied on flat surfaces, their use on micro- and nanoparticles remains largely unexplored, despite the widespread experimental (specifically, clinical) uncertainties that arise because of biofouling. Here, we describe the preparation of magnetic micron-sized beads coated with zwitterionic sulfobetaine polymer brushes that display strong antifouling characteristics. These coated beads can then be equipped with recognition elements of choice, to enable the specific binding of target molecules. First, we present a proof of principle with biotin-functionalized beads that are able to specifically bind fluorescently labeled streptavidin from a complex mixture of serum proteins. Moreover, we show the versatility of the method by demonstrating that it is also possible to functionalize the beads with mannose moieties to specifically bind the carbohydrate-binding protein concanavalin A. Flow cytometry was used to show that thus-modified beads only bind specifically targeted proteins, with minimal/near-zero nonspecific protein adsorption from other proteins that are present. These antifouling zwitterionic polymer-coated beads, therefore, provide a significant advancement for the many bead-based diagnostic and other biosensing applications that require stringent antifouling conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.