SynthesisDepression and anxiety2018
Understanding suicide risk within the Research Domain Criteria (RDoC) framework: A meta-analytic review.
Synthesis in Depression and anxiety, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Neuroscience-informed classification of prevention interventions in substance use disorders: An RDoC-based approach.Neuroscience and biobehavioral reviews · 2024Pooled it
- Self-injurious thoughts and behaviors and alterations in positive valence systems: A systematic review of the literature.Journal of psychiatric research · 2022Pooled it
- Objective measurement of sleep, heart rate, heart rate variability, and physical activity in suicidality: A systematic review.Journal of affective disorders · 2020Pooled it
- Immersive and reflective recall of a suicidal episode: Implications for assessing and treating suicidal adolescents.Journal of consulting and clinical psychology · 2023Trial
- Neural responsiveness to reward and suicidal ideation in social anxiety and major depression before and after psychotherapy.Biological psychology · 2023Trial
- Effects of acute estradiol and progesterone on perimenstrual exacerbation of suicidal ideation and related symptoms: a crossover randomized controlled trial.Translational psychiatry · 2022Trial
- Suicide attempt history is associated with blunted neural reward responsiveness after accounting for a history of suicidal ideation and preparatory behaviors.Cognitive, affective & behavioral neuroscience · 2026Article
- Potential predictors of future suicide attempts in adolescents assigned female at birth.Journal of affective disorders · 2026Article
- Concurrent and Prospective Prediction of Suicidal Ideation in Adolescents Using Multimethod Data and Machine Learning: A Pilot Study.JAACAP open · 2025Article
- Predicting suicide death among veterans after psychiatric hospitalization using transformer based models with social determinants and NLP.Scientific reports · 2025Article
- Advancing Research on Suicide and Mental Health in Autistic Adults Through a Research Domain Criteria (RDoC)-Inspired Framework.Autism in adulthood · 2025Article
- Heightened effective connectivity of DLPFC-mPFC and DLPFC-ACC circuits in major depressive disorder with suicidal ideation: evidence from a TMS-EEG study.Translational psychiatry · 2025Article
- Girls with higher levels of suicidal ideation experienced less parental reciprocity of eye-contact and positive facial affect during conflictual interactions: A pilot study.Development and psychopathology · 2025Article
- Perseverative cognitions, negative valence systems, positive valence systems, social disconnection, and suicide: testing a mediator model among university students.BMC psychology · 2025Article
- Suicide Ideation Severity and Oculomotor Avoidance of Suicide-Related Stimuli.Suicide & life-threatening behavior · 2025Article
- Digital phenotyping of depression during pregnancy using self-report data.Journal of affective disorders · 2024Observational
- Genetics of suicide ideation. A role for inflammation and neuroplasticity?European archives of psychiatry and clinical neuroscience · 2024Article
- Immigration Status, Legal Vulnerability, and Suicidal/Self-harm Ideation Disparities Among Immigrant-Origin Latinx Young Adults in the U.S.Journal of racial and ethnic health disparities · 2024Article
- Clinical, behavioral, and electrophysiological profiles along a continuum of suicide risk: evidence from an implicit association task.Psychological medicine · 2024Article
- Theta oscillatory dynamics serving cognitive control index psychosocial distress in youth.Neurobiology of stress · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe field is in need of novel and transdiagnostic risk factors for suicide. The National Institute of Mental Health's Research Domain Criteria (RDoC) provides a framework that may help advance research on suicidal behavior.
methodWe conducted a meta-analytic review of existing prospective risk and protective factors for suicidal thoughts and behaviors (ideation, attempts, and deaths) that fall within one of the five RDoC domains or relate to a prominent suicide theory. Predictors were selected from a database of 4,082 prospective risk and protective factors for suicide outcomes.
resultsA total of 460 predictors met inclusion criteria for this meta-analytic review and most examined risk (vs. protective) factors for suicidal thoughts and behaviors. The overall effect of risk factors was statistically significant, but relatively small, in predicting suicide ideation (weighted mean odds ratio: wOR = 1.72; 95% CI: 1.59-1.87), suicide attempt (wOR = 1.66 [1.57-1.76), and suicide death (wOR = 1.41 [1.24-1.60]). Across all suicide outcomes, most risk factors related to the Negative Valence Systems domain, although effect sizes were of similar magnitude across RDoC domains.
conclusionsThis study demonstrated that the RDoC framework provides a novel and promising approach to suicide research; however, relatively few studies of suicidal behavior fit within this framework. Future studies must go beyond the "usual suspects" of suicide risk factors (e.g., mental disorders, sociodemographics) to understand the processes that combine to lead to this deadly outcome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.