ArticleInternational journal of obesity (2005)2018
Brain substrates of unhealthy versus healthy food choices: influence of homeostatic status and body mass index.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- The effect of hunger state on hypothalamic functional connectivity in response to food cues.Human brain mapping · 2023Article
- Neural underpinnings of food choice and consumption in obesity.International journal of obesity (2005) · 2022Article
- Functional Connectivity of the Chemosenses: A Review.Frontiers in systems neuroscience · 2022Review
- Food preference assay in male and female C57BL/6 mice.Journal of neuroscience methods · 2022Article
- Neural network modelling reveals changes in directional connectivity between cortical and hypothalamic regions with increased BMI.International journal of obesity (2005) · 2021Article
- Reliability of neural food cue-reactivity in participants with obesity undergoing bariatric surgery: a 26-week longitudinal fMRI study.European archives of psychiatry and clinical neuroscience · 2021Article
- Valence Encoding Signals in the Human Amygdala and the Willingness to Eat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The tenacious brain: How the anterior mid-cingulate contributes to achieving goals.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Review
- Neural Substrates of Food Valuation and Its Relationship With BMI and Healthy Eating in Higher BMI Individuals.Frontiers in behavioral neuroscience · 2020Article
- Motivation in the Service of Allostasis: The Role of anterior Mid Cingulate Cortex.Advances in motivation science · 2019Article
- Invasive and Non-invasive Stimulation of the Obese Human Brain.Frontiers in neuroscience · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesUnhealthy dietary choices are a major contributor to harmful weight gain and obesity. This study interrogated the brain substrates of unhealthy versus healthy food choices in vivo, and evaluated the influence of hunger state and body mass index (BMI) on brain activation and connectivity. SUBJECTS/
methodsThirty adults (BMI: 18-38 kg m
resultsSelecting between unhealthy and healthy foods elicited significant activation in the hypothalamus, the medial and dorsolateral prefrontal cortices, the anterior insula and the posterior cingulate. Hunger was associated with higher activation within the ventromedial and dorsolateral prefrontal cortices, as well as lower connectivity between the hypothalamus and both the ventromedial prefrontal cortex and dorsal striatum. Critically, people with higher BMI showed lower activation of the hypothalamus-regardless of hunger state-and higher activation of the ventromedial prefrontal cortex when hungry.
conclusionsPeople who are overweight and obese have weaker activation of brain regions involved in energy regulation and greater activation of reward valuation regions while making choices between unhealthy and healthy foods. These results provide evidence for a shift towards hedonic-based, and away from energy-based, food selection in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.