Evidence map›Paper›PMID 29064472›Full record

ArticleTranslational psychiatry2017

Genome-wide association studies of smooth pursuit and antisaccade eye movements in psychotic disorders: findings from the B-SNIP study.

R Lencer, L J Mills, N Alliey-Rodriguez, R Shafee, A M Lee, J L Reilly, A Sprenger, J E McDowell, S A McCarroll, M S Keshavan and 6 more

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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  20. Genome-wide association study accounting for anticholinergic burden to examine cognitive dysfunction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 2 countries.

R LencerDepartment of Psychiatry and Psychotherapy, Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany.
L J MillsMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
N Alliey-RodriguezDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
R ShafeeDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
A M LeeDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
J L ReillyDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
A SprengerDepartment of Neurology, University of Luebeck, Luebeck, Germany.ORCID 0000-0001-9255-7911
J E McDowellDepartment of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
S A McCarrollDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
M S KeshavanDepartment of Psychiatry, Harvard Medical School, Beth Israel Deacones Medical Center, Boston, MA, USA.
G D PearlsonDepartments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
C A TammingaDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
B A ClementzDepartment of Psychology and Neuroscience, BioImaging Research Center, University of Georgia, Athens, GA, USA.
E S GershonDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.
J A SweeneyDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
J R BishopDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USUniversity of Chicago · USUniversity of Georgia · USBeth Israel Deaconess Medical Center · USBroad Institute · USCenter for Behavioral Brain Sciences · DEHartford Hospital · USHarvard University · USNorthwestern University · USThe University of Texas Southwestern Medical Center · USUniversity of Cincinnati · USUniversity of Lübeck · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077852 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI THAKER, GUNVANT K · 2007 to 2010
$3.5M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
Neural mechanisms for antisaccade errors among schizophrenia familiesR01MH085485 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A · 2009 to 2013
$1.4M
Schizophrenia Pharmacogenetics: cognition and symptom response to antipsychoticsK08MH083888 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BISHOP, JEFFREY R · 2009 to 2013
$899k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K08 MH083888NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077852NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH085485
6 · The paper itself

Abstract

Eye movement deviations, particularly deficits of initial sensorimotor processing and sustained pursuit maintenance, and antisaccade inhibition errors, are established intermediate phenotypes for psychotic disorders. We here studied eye movement measures of 849 participants from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study (schizophrenia N=230, schizoaffective disorder N=155, psychotic bipolar disorder N=206 and healthy controls N=258) as quantitative phenotypes in relation to genetic data, while controlling for genetically derived ancestry measures, age and sex. A mixed-modeling genome-wide association studies approach was used including ~4.4 million genotypes (PsychChip and 1000 Genomes imputation). Across participants, sensorimotor processing at pursuit initiation was significantly associated with a single nucleotide polymorphism in IPO8 (12p11.21, P=8 × 10

Indexed as

Pursuit, SmoothSaccadesAdultBipolar DisorderFemaleGenome-Wide Association StudyGenotypeHumansMalePhenotypePolymorphism, Single NucleotidePsychotic DisordersSchizophrenia

Identifiers

PMID29064472
PMCPMC5682604
OpenAlexW2765680938

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.