Evidence map›Paper›PMID 29064461›Full record

ReviewInternational journal of environmental research and public health2017

Endocrine Disruptors Leading to Obesity and Related Diseases.

Demetrios Petrakis, Loukia Vassilopoulou, Charalampos Mamoulakis, Christos Psycharakis, Aliki Anifantaki, Stavros Sifakis, Anca Oana Docea, John Tsiaoussis, Antonios Makrigiannakis, Aristides M Tsatsakis

Open access · goldAbstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
30.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it, 188 citations in OpenAlex.

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  14. Endocrine disruptors, obesity, and metabolic syndrome.Turkish journal of medical sciences · 2025
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Demetrios PetrakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. dimitriospetrakis@hotmail.com.
Loukia VassilopoulouDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. loukia.vassilopoulou@gmail.com.
Charalampos MamoulakisDepartment of Urology, University General Hospital of Heraklion, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. mamoulak@uoc.gr.
Christos PsycharakisDepartment of Obstetrics and Gynecology, Venizeleio-Pananio General Hospital of Heraklion, 71409 Heraklion, Crete, Greece. chrispsycharakis@hotmail.com.
Aliki AnifantakiCrete Fertility Center, 56, Arch. Makariou & Sof. Venizelou Str., 71202 Heraklion, Crete, Greece. alikianifantaki@gmail.com.
Stavros SifakisMitera Hospital, 71409 Heraklion, Crete, Greece. stavros.sifakis@yahoo.com.
Anca Oana DoceaDepartment of Toxicology, Faculty of Pharmacy, University of Medicine and Pharmacy, Petru Rares, 200349 Craiova, Romania. ancadocea@gmail.com.
John TsiaoussisLaboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. jtsiaoussis@hotmail.com.
Antonios MakrigiannakisDepartment of Obstetrics and Gynecology, Medical School, University of Crete, 71003 Heraklion, Crete, Greece. makrygia@uoc.gr.
Aristides M TsatsakisDepartment of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Crete, Greece. tsatsaka@uoc.gr.
University of Crete · GRMitera Hospital · GRThe General Hospital of Heraklion "Venizeleio-Pananio" · GRUniversity of Medicine and Pharmacy of Craiova · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

Indexed as

Cardiovascular DiseasesEndocrine DisruptorsFatty LiverHumansInfertilityMetabolic SyndromeNeoplasmsObesityEndocrine Disruptorscarcinogenesiscardiovascular diseasesdiabetes mellitusendocrine disruptorsinfertilitymetabolic syndromeobesitypesticides

Identifiers

PMID29064461
PMCPMC5664782
OpenAlexW2765818725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.