SynthesisInternational journal of environmental research and public health2017
Association between Obesity and Puberty Timing: A Systematic Review and Meta-Analysis.
Synthesis in International journal of environmental research and public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07437976 (A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity), which is not on this map. Cited by 154 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Natural History of Genetic and Environmental Predictors of Pubertal Timing Among Youth With Obesity
Who cites it
154 citing papers in PubMed, 12 syntheses or guidelines pooled it, 355 citations in OpenAlex.
- The relationship between childhood obesity and male puberty development: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- Overweight/Obesity in Childhood and the Risk of Early Puberty: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Green Space Quality and Health: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Green Space and Health in Mainland China: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Pubertal timing in boys and girls born to mothers with gestational diabetes mellitus: a systematic review.European journal of endocrinology · 2021Pooled it
- Nutrient Intake through Childhood and Early Menarche Onset in Girls: Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Timing of Pubertal Milestones in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- Association of obesity with the eruption of first and second permanent molars in children: a systematic review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2020Pooled it
- Association of puberty timing with type 2 diabetes: A systematic review and meta-analysis.PLoS medicine · 2020Pooled it
- Variations in reproductive events across life: a pooled analysis of data from 505 147 women across 10 countries.Human reproduction (Oxford, England) · 2019Pooled it
- Improving adolescents' dietary behavior through teacher-delivered cancer prevention education: a school-based cluster randomized intervention trial in urban Rajasthan.BMC public health · 2024Trial
- Evaluating potential predictors of weight loss response to liraglutide in adolescents with obesity: A post hoc analysis of the randomized, placebo-controlled SCALE Teens trial.Pediatric obesity · 2023Trial
- Positive effect of combined exercise on adipokines levels and pubertal signs in overweight and obese girls with central precocious puberty.Lipids in health and disease · 2021Trial
- Spatiotemporal Patterns of Age at Menarche or Spermarche in Chinese Children and Adolescents and Socioeconomic and Environmental Determinants: Findings from a Series of Nation-Wide Surveys, 1995 to 2019.Environment & health (Washington, D.C.) · 2026Article
- Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?International journal of molecular sciences · 2026Review
- Dlk1-deficient mice achieve puberty despite low body weight and low levels of leptin and kisspeptin.Journal of neuroendocrinology · 2026Article
- Association between childhood weight status and timing of puberty: a systematic review and meta-analysis.Translational pediatrics · 2026Article
- Ambient Air Pollution, Polycyclic Aromatic Hydrocarbons, and Pubertal Development: A Critical Review of Emerging Evidence.Current environmental health reports · 2026Review
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis examined the associations between obesity and puberty timing based on scientific evidence. Eight electronic databases were searched up to February 2017 for eligible studies, and two reviewers screened the articles and extracted the data independently. A total of 11 cohort studies with 4841 subjects met the inclusion criteria. Compared with the group of normal-weight girls, the obese group had more girls with menarche (RR: 1.87, 95% CI: 1.59-2.19, 2 studies). The number of girls with early puberty was significantly higher in the obese group than the normal weight group (RR: 2.44, 95% CI: 1.32-4.52, 5 studies). However, no differences were detected between girls who were obese or normal weight at age of menarche (WMD: -0.53 years, 95% CI: -1.24-0.19, 2 studies). There is no consistent result in the relationship between obesity and timing of pubertal onset in boys. Obesity may contribute to early onset of puberty in girls, while in boys, there is insufficient data. Given the limited number of cohort studies included in this meta-analysis, high-quality studies with strong markers of puberty onset, as well as standardized criteria for defining obesity are needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.