ArticleJournal of cognitive neuroscience2018
The Neurobiology of Agrammatic Sentence Comprehension: A Lesion Study.
Article in Journal of cognitive neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Neurofunctional Correlates of Morphosyntactic and Thematic Impairments in Aphasia: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Neural Resources Supporting Language Production vs. Comprehension in Chronic Post-stroke Aphasia: A Meta-Analysis Using Activation Likelihood Estimates.Frontiers in human neuroscience · 2021Pooled it
- Neural networks for sentence comprehension and production: An ALE-based meta-analysis of neuroimaging studies.Human brain mapping · 2019Pooled it
- An exploratory study and new model of the role of implicit timing in sentence comprehension.Brain and language · 2025Article
- Revisiting the Cerebellum's Linguistic Role: Evidence for Cerebellar Involvement in Expressive Syntax.Cerebellum (London, England) · 2025Article
- Distinct neural correlates of morphosyntactic and thematic comprehension processes in aphasia.Brain communications · 2025Article
- Syntactic Scrambling in Broca's Aphasia: A Turkish Sample.Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP) · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Lesion-symptom Mapping of Acceptability Judgments in Chronic Poststroke Aphasia Reveals the Neurobiological Underpinnings of Receptive Syntax.Journal of cognitive neuroscience · 2024Article
- Atypical characteristic changes of surface morphology and structural covariance network in developmental dyslexia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum.Brain : a journal of neurology · 2024Article
- Verbal working memory and syntactic comprehension segregate into the dorsal and ventral streams, respectively.Brain communications · 2024Article
- Mapping sentence comprehension and syntactic complexity: evidence from 131 stroke survivors.Brain communications · 2024Article
- Causal evidence for a coordinated temporal interplay within the language network.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Syntactic Impairment Associated with Hypoperfusion in the Left Middle and Inferior Frontal Gyri after Right Cerebellar Hemorrhage.Internal medicine (Tokyo, Japan) · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Grammatical Parallelism in Aphasia: A Lesion-Symptom Mapping Study.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Lexico-semantics obscures lexical syntax.Frontiers in language sciences · 2023Article
- The Wernicke conundrum revisited: evidence from connectome-based lesion-symptom mapping.Brain : a journal of neurology · 2022Article
- Structural disconnections associated with language impairments in chronic post-stroke aphasia using disconnectome maps.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
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7 authors.
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Abstract
Broca's area has long been implicated in sentence comprehension. Damage to this region is thought to be the central source of "agrammatic comprehension" in which performance is substantially worse (and near chance) on sentences with noncanonical word orders compared with canonical word order sentences (in English). This claim is supported by functional neuroimaging studies demonstrating greater activation in Broca's area for noncanonical versus canonical sentences. However, functional neuroimaging studies also have frequently implicated the anterior temporal lobe (ATL) in sentence processing more broadly, and recent lesion-symptom mapping studies have implicated the ATL and mid temporal regions in agrammatic comprehension. This study investigates these seemingly conflicting findings in 66 left-hemisphere patients with chronic focal cerebral damage. Patients completed two sentence comprehension measures, sentence-picture matching and plausibility judgments. Patients with damage including Broca's area (but excluding the temporal lobe; n = 11) on average did not exhibit the expected agrammatic comprehension pattern-for example, their performance was >80% on noncanonical sentences in the sentence-picture matching task. Patients with ATL damage ( n = 18) also did not exhibit an agrammatic comprehension pattern. Across our entire patient sample, the lesions of patients with agrammatic comprehension patterns in either task had maximal overlap in posterior superior temporal and inferior parietal regions. Using voxel-based lesion-symptom mapping, we find that lower performances on canonical and noncanonical sentences in each task are both associated with damage to a large left superior temporal-inferior parietal network including portions of the ATL, but not Broca's area. Notably, however, response bias in plausibility judgments was significantly associated with damage to inferior frontal cortex, including gray and white matter in Broca's area, suggesting that the contribution of Broca's area to sentence comprehension may be related to task-related cognitive demands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.