ReviewAmerican journal of respiratory and critical care medicine2018
Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Review in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07302425 (The Effect of the High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation), which is not on this map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of the High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation: a Pilot Study
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- A 7-point evidence-based care discharge protocol for patients hospitalized for exacerbation of COPD: consensus strategy and expert recommendation.NPJ primary care respiratory medicine · 2024Pooled it
- Performance-based outcome measures to assess functionality in hospitalised patients with COPD exacerbations: a systematic review of the measurement properties.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression.Frontiers in nutrition · 2023Pooled it
- Comprehensive multi-cohort transcriptional meta-analysis of muscle diseases identifies a signature of disease severity.Scientific reports · 2022Pooled it
- Sarcopenia in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2019Pooled it
- Development and multicenter validation of machine learning models for 28-day mortality in critically ill patients with acute exacerbation of chronic obstructive pulmonary disease.BMC pulmonary medicine · 2026Article
- Implementing acute exacerbations of COPD care bundles: evidence, effectiveness and future directions.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- The lung-muscle axis in COPD: a conceptual framework integrating evidence, mechanisms, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Screening Utility of Lower Limb Muscle Ultrasound for Sarcopenia in COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Article
- Pectoral muscle area derived from chest computed tomography to identify quadriceps muscle weakness in COPD.ERJ open research · 2025Article
- Muscle Wasting and Treatment of Dyslipidemia in COPD: Implications for Patient Management.Biomedicines · 2025Review
- Aging enhances pro-atrogenic gene expression and skeletal muscle loss following respiratory syncytial virus infection.GeroScience · 2025Article
- Shear wave elastography, as a feasible tool, can be used to reflect the lower limb dysfunction in patients with chronic obstructive pulmonary disease?Scientific reports · 2025Article
- The Role of Diaphragmatic Ultrasound in Identifying Sarcopenia in COPD Patients: A Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Skeletal Muscle Function in Relation to COPD Severity and Its Predictive Significance for Disease Progression.International journal of chronic obstructive pulmonary disease · 2025Article
- Multifaceted associations between walking performance, physical fitness, extremity function, health status, and depression in individuals with COPD.Annals of medicine · 2024Article
- Cognitive interference of respiratoryERJ open research · 2024Article
- Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema.Science advances · 2024Article
- Exploring Balance Impairment and Determinants in Chronic Obstructive Pulmonary Disease: A Comparative Study with Healthy Subjects.Diagnostics (Basel, Switzerland) · 2024Article
- Temporal Dynamics of Cardiovascular Risk in Patients with Chronic Obstructive Pulmonary Disease During Stable Disease and Exacerbations: Review of the Mechanisms and Implications.International journal of chronic obstructive pulmonary disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Important features of both stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) are skeletal muscle weakness and wasting. Limb muscle dysfunction during an exacerbation has been linked to various adverse outcomes, including prolonged hospitalization, readmission, and mortality. The contributing factors leading to muscle dysfunction are similar to those seen in stable COPD: disuse, nutrition/energy balance, hypercapnia, hypoxemia, electrolyte derangements, inflammation, and drugs (i.e., glucocorticoids). These factors may be the trigger for a downstream cascade of local inflammatory changes, pathway process alterations, and structural degradation. Ultimately, the clinical effects can be wide ranging and include reduced limb muscle strength. Current therapies, such as pulmonary/physical rehabilitation, have limited impact because of low participation rates. Recently, novel drugs have been developed in similar disorders, and learnings from these studies can be used as a foundation to facilitate discovery in patients hospitalized with a COPD exacerbation. Nevertheless, investigators should approach this patient population with knowledge of the limitations of each intervention. In this Concise Clinical Review, we provide an overview of acute muscle dysfunction in patients hospitalized with acute exacerbation of COPD and a strategic approach to drug development in this setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.