Evidence map›Paper›PMID 29064106›Full record

ArticleJournal of applied toxicology : JAT2018

Integration of mechanistic and pharmacokinetic information to derive oral reference dose and margin-of-exposure values for hexavalent chromium.

Chad M Thompson, Christopher R Kirman, Sean M Hays, Mina Suh, Seneca E Harvey, Deborah M Proctor, Julia E Rager, Laurie C Haws, Mark A Harris

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied toxicology : JAT, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chad M ThompsonToxStrategies, Inc., Katy, TX, 77494, USA.ORCID 0000-0002-2265-7420
Christopher R KirmanSummit Toxicology, LLP, Bozeman, MT, 59722, USA.
Sean M HaysSummit Toxicology, LLP, Bozeman, MT, 59722, USA.
Mina SuhToxStrategies, Inc., Mission Viejo, CA, 92692, USA.
Seneca E HarveyToxStrategies, Inc., Katy, TX, 77494, USA.
Deborah M ProctorToxStrategies, Inc., Mission Viejo, CA, 92692, USA.
Julia E RagerToxStrategies, Inc., Austin, TX, 78731, USA.
Laurie C HawsToxStrategies, Inc., Austin, TX, 78731, USA.
Mark A HarrisToxStrategies, Inc., Katy, TX, 77494, USA.
BioStrategies (United States) · USSummit School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current US Environmental Protection Agency (EPA) reference dose (RfD) for oral exposure to chromium, 0.003 mg kg

Indexed as

Biological AssayModels, BiologicalAdministration, OralAnimalsCalibrationCarcinogenicity TestsChromiumDose-Response Relationship, DrugEnvironmental PollutantsFemaleHumansIntestinal NeoplasmsMaleMiceNo-Observed-Adverse-Effect LevelRatsChromiumchromium hexavalent ionEnvironmental Pollutantsbenchmark dose (BMD) modelinghexavalent chromium Cr(VI)margin of exposure (MOE)mode of actionreference dose (RfD)risk assessment

Identifiers

PMID29064106
PMCPMC5813206
OpenAlexW2766440237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.