Evidence map›Paper›PMID 29063981›Full record

Observational studyBreast cancer research and treatment2018

The effect of genetic variants on the relationship between statins and breast cancer in postmenopausal women in the Women's Health Initiative observational study.

Cathryn H Bock, Allison M Jay, Gregory Dyson, Jennifer L Beebe-Dimmer, Michele L Cote, Lifang Hou, Barbara V Howard, Pinkal Desai, Kristen Purrington, Ross Prentice and 1 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Breast cancer research and treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Statin therapy: does sex matter?Menopause (New York, N.Y.) · 2019
    Review
  2. Interactions BetweenFrontiers in oncology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Cathryn H BockKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA. bockc@karmanos.org.
Allison M JaySt. John Health System, Van Elslander Cancer Center, 19229 Mack Ave, Grosse Pointe Woods, MI, 48236, USA.
Gregory DysonKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA.
Jennifer L Beebe-DimmerKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA.
Michele L CoteKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA.
Lifang HouDepartment of Preventive Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 675 North St. Clair, Chicago, IL, 60611, USA.
Barbara V HowardMedstar Health Research Institute and Georgetown/Howard Universities Center for Clinical and Translational Science, 6525 Belcrest Road, Suite 700, Hyattsville, MD, 20782, USA.
Pinkal DesaiDivision of Hematology/Oncology, Weill Cornell Medical College, 1300 York Ave, New York, NY, 10065, USA.
Kristen PurringtonKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA.
Ross PrenticeFred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, PO Box 19024, Seattle, WA, 98109, USA.
Michael S SimonKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Detroit, MI, 48201, USA.
Wayne State University · USThe Barbara Ann Karmanos Cancer Institute · USCornell University · USFred Hutch Cancer Center · USMedStar Health · USNorthwestern University · USSt. John Medical Center · US

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
NCATS NIH HHS UL1 TR001409NCI NIH HHS P30 CA022453NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

purposeStatins have been postulated to have chemopreventive activity against breast cancer. We evaluated whether germline genetic polymorphisms modified the relationship between statins and breast cancer risk using data from the Women's Health Initiative. We evaluated these interactions using both candidate gene and agnostic genome-wide approaches.

methodsTo identify candidate gene-statin interactions, we tested interactions between 22 SNPS in nine candidate genes implicated in the effect of statins on lipid metabolism in 1687 cases and 1687 controls. We then evaluated statin use interaction with the remaining 30,380 SNPs available in this sample from the CGEMS GWAS study.

resultsAfter adjusting for multiple comparisons, no SNP interactions with statin usage and risk of breast cancer were statistically significant in either the candidate genes or genome-wide approaches.

conclusionsWe found no evidence of SNP interactions with statin usage for breast cancer risk in a population of 3374 individuals. These results suggest that genome-wide common genetic variants do not moderate the association between statin usage and breast cancer in the population of women in the Women's Health Initiative.

Indexed as

Genetic Predisposition to DiseaseAgedAnticholesteremic AgentsBreast NeoplasmsCholesterolFemaleGenome-Wide Association StudyHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMiddle AgedPolymorphism, Single NucleotidePostmenopauseRisk AssessmentRisk FactorsWomen's HealthAnticholesteremic AgentsCholesterolHydroxymethylglutaryl-CoA Reductase InhibitorsBreast cancerCholesterolGWASSNPSStatins

Identifiers

PMID29063981
PMCPMC5809196
OpenAlexW2766839758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.