ArticleAngewandte Chemie (International ed. in English)2017
Direct Aryl C-H Amination with Primary Amines Using Organic Photoredox Catalysis.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed.
- Electrochemical oxidation enables aromatic C-H amination with dual mechanisms.Nature synthesis · 2026Article
- Photocatalytic Addition ofOrganic letters · 2025Article
- Arene and Heteroarene Functionalization Enabled by Organic Photoredox Catalysis.Accounts of chemical research · 2025Article
- Synthesis of Biaryl Atropisomers via Site-Selective C-H Functionalization.Organic letters · 2025Article
- One-Step Synthesis of [ACS central science · 2024Article
- Visible-Light Photocatalytic C-H Amination of Arenes Utilizing Acridine-Lewis Acid Complexes.Journal of the American Chemical Society · 2024Article
- Ground State Generation and Cyclization of Aminium Radicals in the Formation of Tetrahydroquinolines.Organic letters · 2024Article
- Site-Selective Electrochemical Arene C-H Amination.Journal of the American Chemical Society · 2024Article
- In(OTf)Chemical science · 2023Article
- Combining photoredox catalysis and hydrogen atom transfer for dearomative functionalization of electron rich heteroarenes.Chemical science · 2023Article
- Photocatalytic Sulfonyl Fluorination of Alkyl Organoboron Substrates.ACS catalysis · 2023Article
- Chemoselective Decarboxylative Protonation Enabled by Cooperative Earth-Abundant Element Catalysis.Angewandte Chemie (International ed. in English) · 2023Article
- Photochemical C(spAngewandte Chemie (International ed. in English) · 2022Article
- Two Paths to Oxidative C-H Amination Under Basic Conditions: A Theoretical Case Study Reveals Hidden Opportunities Provided by Electron Upconversion.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Chemoenzymatic Asymmetric Synthesis of Complex Heterocycles: Dihydrobenzoxazinones and Dihydroquinoxalinones.ACS catalysis · 2022Article
- Selective skeletal editing of polycyclic arenes using organophotoredox dearomative functionalization.Nature communications · 2022Article
- Photons or Electrons? A Critical Comparison of Electrochemistry and Photoredox Catalysis for Organic Synthesis.Chemical reviews · 2022Review
- Photoredox-Catalyzed C-H Functionalization Reactions.Chemical reviews · 2022Review
- Strategies to Generate Nitrogen-centered Radicals That May Rely on Photoredox Catalysis: Development in Reaction Methodology and Applications in Organic Synthesis.Chemical reviews · 2022Review
- Aryl Transfer Strategies Mediated by Photoinduced Electron Transfer.Chemical reviews · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The direct catalytic C-H amination of arenes is a powerful synthetic strategy with useful applications in pharmaceuticals, agrochemicals, and materials chemistry. Despite the advances in catalytic C-H functionalization, the use of aliphatic amine coupling partners is limited. Described herein is the construction of C-N bonds, using primary amines, by direct C-H functionalization with an acridinium photoredox catalyst under an aerobic atmosphere. A wide variety of primary amines, including amino acids and more complex amines are competent coupling partners. Various electron-rich aromatics and heteroaromatics are useful scaffolds in this reaction, as are complex, biologically active arenes. We also describe the ability to functionalize arenes that are not oxidized by an acridinium catalyst, such as benzene and toluene, thus supporting a reactive amine cation radical intermediate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.