ReviewCurrent topics in behavioral neurosciences
The Future of Contextual Fear Learning for PTSD Research: A Methodological Review of Neuroimaging Studies.
Review in Current topics in behavioral neurosciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Impaired mnemonic pattern separation associated with PTSD symptoms paradoxically improves with regular cannabis use.Npj mental health research · 2025Article
- Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization.Advances in neurobiology · 2024Review
- Altered frontolimbic activity during virtual reality-based contextual fear learning in patients with posttraumatic stress disorder.Psychological medicine · 2023Article
- Characterizing the neural circuitry associated with configural threat learning.Brain research · 2019Article
- Cholinergic Signaling Alters Stress-Induced Sensitization of Hippocampal Contextual Learning.Frontiers in neuroscience · 2019Article
- Neural measures associated with configural threat acquisition.Neurobiology of learning and memory · 2018Article
- Framework for Accurate Classification of Self-Reported Stress From Multisession Functional MRI Data of Veterans With Posttraumatic Stress.Chronic stress (Thousand Oaks, Calif.)Article
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Authors and funding
5 authors.
Funding
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Abstract
There has been a great deal of recent interest in human models of contextual fear learning, particularly due to the use of such paradigms for investigating neural mechanisms related to the etiology of posttraumatic stress disorder. However, the construct of "context" in fear conditioning research is broad, and the operational definitions and methods used to investigate contextual fear learning in humans are wide ranging and lack specificity, making it difficult to interpret findings about neural activity. Here we will review neuroimaging studies of contextual fear acquisition in humans. We will discuss the methodology associated with four broad categories of how contextual fear learning is manipulated in imaging studies (colored backgrounds, static picture backgrounds, virtual reality, and configural stimuli) and highlight findings for the primary neural circuitry involved in each paradigm. Additionally, we will offer methodological recommendations for human studies of contextual fear acquisition, including using stimuli that distinguish configural learning from discrete cue associations and clarifying how context is experimentally operationalized.
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