SynthesisClinical oral investigations2018
Does smoking habit increase the micronuclei frequency in the oral mucosa of adults compared to non-smokers? A systematic review and meta-analysis.
Synthesis in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The smokeless tobacco habit and DNA damage: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2019Pooled it
- Use of infrared photobiomodulation with low-level laser therapy for reduction of bleaching-induced tooth sensitivity after in-office bleaching: a double-blind, randomized controlled trial.Lasers in medical science · 2022Trial
- Increased genotoxicity in human corneal epithelial cells associated with keratoconus.International ophthalmology · 2026Article
- Association Between E-Cigarette Use (Vaping) and Oral Health in Adolescents and Young Adults: A Systematic Review.Journal of clinical medicine · 2026Review
- Impact of cigarette smoking on genetic stability, cell division, and cytotoxicity in buccal cells of old and young women.Mutagenesis · 2026Article
- Cytomorphological changes of oral mucosal cells among smokeless tobacco users in low and middle-income country settings: new findings from Pakistan.BMC oral health · 2024Article
- Amelioration of Cytogenotoxic Damage in Drug Abusers Supplemented with Folic Acid.Biomedicines · 2024Article
- Micronuclei detection in oral cytologic smear: does it add diagnostic value?Journal of the Egyptian National Cancer Institute · 2023Article
- Reply to the opinion paper: is micronucleus test a suitable method for monitoring oral mucosa exposed to dental bleachings in smokers?Archives of toxicology · 2023Article
- Re: Evaluation of Micronuclei and Cytomorphometric Changes in Patients with Different Tobacco Related Habits Using Exfoliated Buccal Cells.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Evaluation of the genetic damage to workers in a Greek shipyard.Industrial health · 2022Article
- Early Diagnosis of Oral Mucosal Alterations in Smokers and E-Cigarette Users Based on Micronuclei Count: A Cross-Sectional Study among Dental Students.International journal of environmental research and public health · 2021Article
- Letter to Editor: The smokeless tobacco habit and DNA damage: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2020Article
- Re: Repair Index in Examination of Nuclear Changes in the Buccal Mucosa of Smokers: A Useful Method for Screening of Oral Cancer.Asian Pacific journal of cancer prevention : APJCP · 2019Article
- Method validation to assess in vivo cellular and subcellular changes in buccal mucosa cells and saliva following CBCT examinations.Dento maxillo facial radiology · 2019Article
- Do dental bleaching agents induce genetic damage on oral mucosa cells?Clinical oral investigations · 2019Article
- Re: Does smoking habit increase the micronuclei frequency in the oral mucosa of adults compared to non-smokers? A systematic review and meta-analysis. de Geus et al., Clin Oral Investig. 2018 Jan; 22(1):81-91.Clinical oral investigations · 2019Article
- Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China.Dose-response : a publication of International Hormesis SocietyArticle
- Micronuclei in Exfoliated Cells: A Biomarker of Genotoxicity in Tobacco Users.Nigerian journal of surgery : official publication of the Nigerian Surgical Research SocietyArticle
- Are healthcare workers immunized after receiving hepatitis B vaccination according to recommended guidelines? A systematic review and meta-analysis.International journal of health sciencesReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesA systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. MATERIALS AND
methodsA comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Cochrane Library and SIGLE without restrictions. Dissertations and thesis were searched using the ProQuest Dissertations and Periodicos Capes Thesis Databases. We included only cross-sectional clinical trials that compared the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients. DATA: After the removal of duplicates, 1338 articles were identified. After title and abstract screening, 35 studies remained. Eighteen studies were further excluded, whereas 17 studies remained for qualitative analysis and 16 for the meta-analysis of the primary and secondary outcomes. A significant difference in the frequency of micronuclei in smokers when compared to non-smokers was observed in the present study.
conclusionsDespite the high variation in the methodology of the assessed studies, this study showed a higher frequency of micronuclei in exfoliated cells of smokers compared to non-smokers. CLINICAL SIGNIFICANCE: The use of tobacco is associated with cytotoxic and genotoxic effects because a higher frequency of micronuclei in exfoliated cells of smokers was observed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.