Evidence map›Paper›PMID 29063380›Full record

ReviewCurrent obesity reports2017

What Twin Studies Tell Us About Brain Responses to Food Cues.

Ellen Schur, Susan Carnell

Open access · greenAbstract readReview
In one paragraph

Review in Current obesity reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Review
  3. Questioning the validity of food addiction: a critical review.Frontiers in behavioral neuroscience · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Central Nervous System and Peripheral Hormone Responses to a Meal in Children.The Journal of clinical endocrinology and metabolism · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ellen SchurUniversity of Washington, 325 Ninth Ave, Box 359780, Seattle, WA, 98104-2420, USA. ellschur@u.washington.edu.
Susan CarnellJohns Hopkins University, 600 N. Wolfe Street, Phipps 300, Baltimore, MD, 21287, USA.
Johns Hopkins University · USUniversity of Washington · US

Funding

PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
A twin study of obesity pathogenesis using fMRIR01DK089036 · NIDDK · UNIVERSITY OF WASHINGTON · PI SCHUR, ELLEN A · 2011 to 2022
$6.2M
Brain systems and behaviors underlying response to obesity treatment in childrenR01DK098466 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI ROTH, CHRISTIAN LUDWIG · 2014 to 2023
$5.6M
NIDDK NIH HHS P30 DK035816NIDDK NIH HHS R01 DK089036NIDDK NIH HHS R01 DK098466
6 · The paper itself

Abstract

purpose of reviewFunctional magnetic resonance imaging (fMRI) using visual food cues provides insight into brain regulation of appetite in humans. This review sought evidence for genetic determinants of these responses. RECENT

findingsEchoing behavioral studies of food cue responsiveness, twin study approaches detect significant inherited influences on brain response to food cues. Both polygenic (whole genome) factors and polymorphisms in single genes appear to impact appetite regulation, particularly in brain regions related to satiety perception. Furthermore, genetic confounding might underlie findings linking obesity to stereotypical response patterns on fMRI, i.e., associations with obesity may actually reflect underlying inherited susceptibilities rather than acquired levels of adiposity. Insights from twin studies show that genes powerfully influence brain regulation of appetite, emphasizing the role of inherited susceptibility factors in obesity risk. Future research to delineate mechanisms of inherited obesity risk could lead to novel or more targeted interventional approaches.

Indexed as

Brain WavesCuesFeeding BehaviorPolymorphism, Single NucleotideAdiposityAppetite RegulationBrainBrain MappingEatingGenetic Predisposition to DiseaseHeredityHumansInheritance PatternsMagnetic Resonance ImagingObesityPedigreeAppetite regulationfMRIFood cuesGeneticsObesityTwin studies

Identifiers

PMID29063380
PMCPMC5716899
OpenAlexW2767117643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.