Evidence map›Paper›PMID 29063370›Full record

ArticleJournal of cell communication and signaling2018

Pathways of production and delivery of hepatocyte exosomes.

Li Chen, Ruju Chen, Sherri Kemper, David R Brigstock

Open access · greenAbstract read
In one paragraph

Article in Journal of cell communication and signaling, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Extracellular vesicles: emerging therapeutic agents for liver fibrosis.Extracellular vesicles and circulating nucleic acids · 2025
    Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Identification of an FMNL2 Interactome by Quantitative Mass Spectrometry.International journal of molecular sciences · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Li ChenCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Ruju ChenCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
Sherri KemperCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
David R BrigstockCenter for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. David.Brigstock@NationwideChildrens.Org.ORCID http://orcid.org/0000-0001-8651-6486
Nationwide Children's Hospital · US

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Thomas M McIntyre · 2016 to 2026
$19.6M
MicroRNA regulation of CTGF in hepatic stellate cellsR01AA021276 · NIAAA · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRIGSTOCK, DAVID R · 2012 to 2016
$1.6M
Hepatocyte Exosomes for Therapy of Ethanol-Induced Liver InjuryR21AA025974 · NIAAA · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRIGSTOCK, DAVID R · 2017 to 2018
$395k
Exosome platforms for assessment and therapy of chronic liver diseaseR21AA023626 · NIAAA · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BRIGSTOCK, DAVID R · 2015 to 2016
$392k
NIAAA NIH HHS P50 AA024333NIAAA NIH HHS P50AA024333NIAAA NIH HHS R01 AA021276NIAAA NIH HHS R01AA021276NIAAA NIH HHS R21 AA023626NIAAA NIH HHS R21AA023626NIAAA NIH HHS R21 AA025974NIAAA NIH HHS R21AA025974
6 · The paper itself

Abstract

Hepatocyte exosomes (Exo

Indexed as

AlcoholCeramideESCRTExtracellular vesicleHepatic stellate cellLiver

Identifiers

PMID29063370
PMCPMC5842184
OpenAlexW2766978094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.