Evidence map›Paper›PMID 29063307›Full record

Trial reportSurgical endoscopy2018

Prospective evaluation of poly-4-hydroxybutyrate mesh in CDC class I/high-risk ventral and incisional hernia repair: 18-month follow-up.

John Scott Roth, Gary J Anthone, Don J Selzer, Benjamin K Poulose, James G Bittner, William W Hope, Raymond M Dunn, Robert G Martindale, Matthew I Goldblatt, David B Earle and 8 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Surgical endoscopy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

John Scott RothDepartment of Surgery, University of Kentucky Medical Center, 800 Rose Street, #C225, Lexington, KY, 40536, USA. s.roth@uky.edu.
Gary J AnthoneDepartment of Surgery, Methodist Health System, Omaha, NE, USA.
Don J SelzerDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Benjamin K PouloseDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
James G BittnerDepartment of Surgery, Virginia Commonwealth University, Richmond, VA, USA.
William W HopeDepartment of Surgery, New Hanover Regional Medical Center, Wilmington, NC, USA.
Raymond M DunnDepartment of Surgery, University of Massachusetts Worcester, Worcester, MA, USA.
Robert G MartindaleDepartment of Surgery, Oregon Health & Science University, Portland, OR, USA.
Matthew I GoldblattDepartment of Surgery, The Medical College of Wisconsin, Inc., Milwaukee, WI, USA.
David B EarleDepartment of Surgery, Baystate Medical Center, Springfield, MA, USA.
John R RomanelliDepartment of Surgery, Baystate Medical Center, Springfield, MA, USA.
Gregory J ManciniDepartment of Surgery, The University of Tennessee Health Science Center, Memphis, TN, USA.
Jacob A GreenbergDepartment of Surgery, Board of Regents of the University of Wisconsin System, Madison, WI, USA.
John G LinnDepartment of Surgery, North Shore University Health System, Evanston, IL, USA.
Eduardo Parra-DavilaDepartment of Surgery, Celebration Health, Celebration, FL, USA.
Bryan J SandlerDepartment of Surgery, The Regents of the University of California, San Diego, CA, USA.
Corey R DeekenCovalent Bio, LLC, St. Louis, MO, USA.
Guy R VoellerDepartment of Surgery, The University of Tennessee Health Science Center, Memphis, TN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong-term resorbable mesh represents a promising technology for complex ventral and incisional hernia repair (VIHR). Preclinical studies indicate that poly-4-hydroxybutyrate (P4HB) resorbable mesh supports strength restoration of the abdominal wall. This study evaluated outcomes of high-risk subjects undergoing VIHR with P4HB mesh.

methodsThis was a prospective, multi-institutional study of subjects undergoing retrorectus or onlay VIHR. Inclusion criteria were CDC Class I, defect 10-350 cm

resultsOne hundred and twenty-one subjects (46M, 75F) with an age of 54.7 ± 12.0 years and BMI of 32.2 ± 4.5 kg/m

conclusionsHigh-risk VIHR with P4HB mesh demonstrated positive outcomes and low incidence of hernia recurrence at 18 months. Longer-term 36-month follow-up is ongoing.

Indexed as

HydroxybutyratesSurgical MeshAdultAgedFemaleFollow-Up StudiesHernia, VentralHerniorrhaphyHumansIncidenceIncisional HerniaMaleMiddle AgedPostoperative ComplicationsProspective StudiesQuality of LifeHydroxybutyratesHernia repairInfectionMeshPoly-4-hydroxybutyrateRecurrenceSeroma

Identifiers

PMID29063307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.