Evidence map›Paper›PMID 29063226›Full record

ArticleWorld journal of surgery2018

Induced Granulation Tissue but not Artificial Dermis Enhances Early Host-Graft Interactions in Full-Thickness Burn Wounds.

Heli Lagus, Esko Kankuri, Kristo Nuutila, Susanna Juteau, Maarit Sarlomo-Rikala, Jyrki Vuola

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In one paragraph

Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Heli LagusDepartment of Surgery, Lohja Hospital, The Hospital District of Helsinki and Uusimaa, Lohja, Finland. heli.lagus@hus.fi.
Esko KankuriDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
Kristo NuutilaDepartment of Pharmacology, Faculty of Medicine, University of Helsinki, P.O. Box 63, 00014, Helsinki, Finland.
Susanna JuteauDepartment of Pathology, Haartman Institute, University of Helsinki and HUSLAB, P.O. Box 21, 00014, Helsinki, Finland.
Maarit Sarlomo-RikalaDepartment of Pathology, Haartman Institute, University of Helsinki and HUSLAB, P.O. Box 21, 00014, Helsinki, Finland.
Jyrki VuolaDepartment of Plastic Surgery, Helsinki University Hospital, P.O. Box 266, 00029, Helsinki, Finland.
University of Helsinki · FIHospital District of Helsinki and Uusimaa · FIHelsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCellular grafts used for skin repair require rapid integration with the host tissue to remain viable and especially to nourish the epidermal cells. Here, we evaluated the responses in the split-thickness skin grafts (STSGs) grafted on three differently treated wound beds: directly on excised wound bed (EX), on an artificial dermal template (DT) and on granulation tissue (GT) induced by cellulose sponge.

methodsIn ten burn patients, after excision, a test area was divided into three sections: One transplanted with STSG instantaneously and two sections had a pre-treatment for 2 weeks with either DT or a cellulose sponge inducing granulation tissue formation and thereafter grafted with STSGs.

resultsOne week after grafting, the STSGs on GT demonstrated most endothelial CD31

conclusionsResults show that pre-treatment of wound bed and induction of granulation tissue formation can accelerate host-graft interaction by stimulating graft vasculature and inducing cell proliferation.

Indexed as

AdultAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAutograftsBlood VesselsBurnsCD163 AntigenCell ProliferationDermisEndotheliumEpidermal CellsEpidermisFemaleGranulation TissueHumansAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenKi-67 AntigenPlatelet Endothelial Cell Adhesion Molecule-1Receptors, Cell Surface

Identifiers

PMID29063226
OpenAlexW2765716698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.