ArticleEuropean journal of pediatrics2018
Late-onset sepsis due to urinary tract infection in very preterm neonates is not uncommon.
Article in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06893939 (Limited Versus Extended Trophic Feeding), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Limited Versus Extended Trophic Feeding (LET-FEED) Trial
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Antibiotic treatment for neonatal sepsis: changing trends and future directions.Drugs in context · 2026Review
- Neonatal point-of-care ultrasound-guidelines for training, credentialing and quality assurance.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Consequences of host-microbiome interactions in preterm infants.Infection and immunity · 2025Review
- Epidemiology of bacterial and fungal infections among level IV neonatal units in North America.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- ETIOLOGY OF URINARY TRACT INFECTIONS IN NEONATES AND BACTERIAL RESISTANCE IN CROATIA.Acta clinica Croatica · 2024Article
- Maternal-Newborn ABO Blood Groups and Risk of Bacterial Infection in Newborns.JAMA network open · 2024Article
- D-dimer as a Useful Biomarker in Early Diagnosis of Neonatal Sepsis: A Single-Center Study From Romania.Cureus · 2024Article
- Association Between Antibiotic Duration and Recurrence of Urinary Tract Infection in the Neonatal Critical Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024Article
- Urinary Tract Infection Epidemiology in NICUs in the United States.American journal of perinatology · 2024Observational
- Prenatal and Postnatal Disparities in Very-Preterm Infants in a Study of Infections between 2018-2023 in Southeastern US.Tropical medicine and infectious disease · 2024Article
- Late-Onset Sepsis Evaluation and Empiric Therapy in Extremely Low Gestational Age Newborns.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Antibiogram of Urinary Tract Infections and Sepsis among Infants in Neonatal Intensive Care Unit.Children (Basel, Switzerland) · 2022Article
- Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective.Frontiers in pediatrics · 2022Review
- Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications.International journal of environmental research and public health · 2021Article
- Challenges in developing a consensus definition of neonatal sepsis.Pediatric research · 2020Review
- Urinary Tract Infection in Children.Recent patents on inflammation & allergy drug discovery · 2019Article
- Urinary tract infection is common in VLBW infants.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary tract infection (UTI) is a common cause of sepsis in infants. Premature infants hospitalized at a neonatal intensive care unit often have risk factors for infection. In this group, the risk of UTI is not clearly known, and guidelines for urine analysis are not unanimous. We aimed to identify the risk of UTI in premature infants with central lines, suspected of late-onset sepsis. We analyzed all 1402 infants admitted to our hospital between 2006 and 2014 with a gestational age less than 32 weeks. Six hundred sixty-two episodes of sepsis evaluations were found with an unknown source of infection based on clinical symptoms. In half of this group, urine analysis was performed identifying UTI in 11.3% (24/212). In 13 of these infants (54%) with a UTI, infection was due to Candida albicans. In at least four episodes, the diagnosis and treatment would have been delayed if urine analysis had not been performed.
conclusionBased on these findings, we conclude that in premature infants with central lines, urine analysis should be performed routinely when signs of infection occur beyond 72 h after birth. Urine collection should not be delayed and cultures should preferably be performed before the start of the antibiotic treatment. What is known: • In preterm infants, the presence of other risk factors for infection might make clinicians reluctant to obtain urine cultures during sepsis evaluation. • An internal survey demonstrated that there is no consensus within the NICUs in The Netherlands regarding urine analysis as part of LOS work-up. What is new: • The risk of UTI in the NICU population (11.3%) is comparable to term infants; therefore, urine analysis should be performed routinely when LOS is suspected. • Candida albicans was the most frequently (54%) detected pathogen causing UTI in this population.
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