Evidence map›Paper›PMID 29062961›Full record

ArticleSynthetic and systems biotechnology2017

Novel polysaccharide-protein conjugates provide an immunogenic 13-valent pneumococcal conjugate vaccine for

Allison E B Turner, Jonas E Gerson, Helen Y So, Daniel J Krasznai, Adrienne J St Hilaire, Donald F Gerson

Open access · goldAbstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Allison E B TurnerVaccine Research and Development, PnuVax Incorporated Headquarters, 134 Albert St., Kingston, Ontario, K7L 3V2, Canada.
Jonas E GersonVaccine Research and Development, PnuVax Incorporated Headquarters, 134 Albert St., Kingston, Ontario, K7L 3V2, Canada.
Helen Y SoVaccine Research and Development, PnuVax Incorporated Laboratories, 6000 Royalmount Ave., Montreal, Quebec, H4P 2T1, Canada.
Daniel J KrasznaiVaccine Research and Development, PnuVax Incorporated Laboratories, 6000 Royalmount Ave., Montreal, Quebec, H4P 2T1, Canada.
Adrienne J St HilaireVaccine Research and Development, PnuVax Incorporated Laboratories, 6000 Royalmount Ave., Montreal, Quebec, H4P 2T1, Canada.
Donald F GersonVaccine Research and Development, PnuVax Incorporated Headquarters, 134 Albert St., Kingston, Ontario, K7L 3V2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pneumonia remains the single leading cause of childhood death worldwide. Despite the commercial availability of multiple pneumococcal conjugate vaccines (PCVs), high dosage cost and supply shortages prevent PCV delivery to much of the developing world. The current work presents high-yield pneumococcal conjugates that are immunogenic in animals and suitable for use in human vaccine development. The 13-valent pneumococcal conjugate vaccine (PCV-13) investigated in this research incorporated serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. Pneumococcal polysaccharides (PnPSs) and CRM

Indexed as

Carrier proteinIn vacuo glycationPCVPneumococcal conjugate vaccinePneumoniaPolysaccharideVaccine development

Identifiers

PMID29062961
PMCPMC5625727
OpenAlexW2578166202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.