Evidence map›Paper›PMID 29062956›Full record

ReviewSynthetic and systems biotechnology2017

Development of fungal cell factories for the production of secondary metabolites: Linking genomics and metabolism.

Jens Christian Nielsen, Jens Nielsen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Synthetic and systems biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Unveiling Metabolic Capability and Growth Adaptation ofInternational journal of molecular sciences · 2026
    Article
  2. Review
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  6. Towards engineering agaricomycete fungi for terpenoid production.Journal of industrial microbiology & biotechnology · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Molecules (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
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  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jens Christian NielsenChalmers University of Technology, Kemivägen 10, Sweden.
Jens NielsenChalmers University of Technology, Kemivägen 10, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genomic era has revolutionized research on secondary metabolites and bioinformatics methods have in recent years revived the antibiotic discovery process after decades with only few new active molecules being identified. New computational tools are driven by genomics and metabolomics analysis, and enables rapid identification of novel secondary metabolites. To translate this increased discovery rate into industrial exploitation, it is necessary to integrate secondary metabolite pathways in the metabolic engineering process. In this review, we will describe the novel advances in discovery of secondary metabolites produced by filamentous fungi, highlight the utilization of genome-scale metabolic models (GEMs) in the design of fungal cell factories for the production of secondary metabolites and review strategies for optimizing secondary metabolite production through the construction of high yielding platform cell factories.

Indexed as

Biosynthetic gene clustersCell factoriesFungiGenome miningMetabolic modelingSecondary metabolism

Identifiers

PMID29062956
PMCPMC5625732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.