Evidence map›Paper›PMID 29062936›Full record

ArticleSynthetic and systems biotechnology2016

Informatic analysis reveals

Chad W Johnston, Jonathan Plumb, Xiang Li, Sergio Grinstein, Nathan A Magarvey

Abstract read
In one paragraph

Article in Synthetic and systems biotechnology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Mucin stimulates the growth ofMicrobiology (Reading, England) · 2026
    Article
  2. Article
  3. TheFrontiers in veterinary science · 2021
    Article
  4. Article
  5. Article
  6. Review
  7. Acyl Histidines: New N-Acyl Amides from Legionella pneumophila.Chembiochem : a European journal of chemical biology · 2017
    Article
  8. Article
  9. PeerJ · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chad W JohnstonThe Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.
Jonathan PlumbCell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Xiang LiThe Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.
Sergio GrinsteinCell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8.
Nathan A MagarveyThe Michael G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial natural products are a crucial source of bioactive molecules and unique chemical scaffolds. Despite their importance, rediscovery of known natural products from established productive microbes has led to declining interest, even while emergent genomic data suggest that the majority of microbial natural products remain to be discovered. Now, new sources of microbial natural products must be defined in order to provide chemical scaffolds for the next generation of small molecules for therapeutic, agricultural, and industrial purposes. In this work, we use specialized bioinformatic programs, genetic knockouts, and comparative metabolomics to define the genus

Indexed as

LC, liquid chromatographyLegionellaMS, mass spectrometryNatural productsNRPS, nonribosomal peptide synthetasePCA, principal component analysisPKS, polyketide synthasePolyketidesPRISM

Identifiers

PMID29062936
PMCPMC5640695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.