Evidence map›Paper›PMID 29062912›Full record

ArticleWellcome open research2017

Differential response of the liver to bile acid treatment in a mouse model of Niemann-Pick disease type C.

Elena-Raluca Nicoli, Mylene Huebecker, David Smith, Lauren Morris, Frances M Platt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wellcome open research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 3 countries.

Elena-Raluca NicoliDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.ORCID https://orcid.org/0000-0002-5545-630X
Mylene HuebeckerDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.ORCID https://orcid.org/0000-0003-3030-7110
David SmithDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.ORCID https://orcid.org/0000-0002-9845-5913
Lauren MorrisDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.
Frances M PlattDepartment of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.ORCID https://orcid.org/0000-0001-7614-0403
University of Notre Dame · US

Funding

Wellcome Trust 202834/Z/16/Z
6 · The paper itself

Abstract

Niemann-Pick disease type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in the

Indexed as

bile acidscholic acidliverlysosomal storage diseaseNiemann Pick disease type CNPC1p450ursodeoxycholic acid

Identifiers

PMID29062912
PMCPMC5639931
OpenAlexW2753266992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.