ArticleeNeuro
Neuronal Intrinsic Physiology Changes During Development of a Learned Behavior.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Post-synaptic facilitation and network dynamics underlying stimulus-specific combination sensitivity.iScience · 2026Article
- Bursts from the past: Intrinsic properties link a network model to zebra finch song.bioRxiv : the preprint server for biology · 2025Article
- Variable and slow-paced neural dynamics in HVC underlie plastic song production in juvenile zebra finches.BMC neuroscience · 2024Article
- Estrogens rapidly shape synaptic and intrinsic properties to regulate the temporal precision of songbird auditory neurons.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Effects of Cortical FoxP1 Knockdowns on Learned Song Preference in Female Zebra Finches.eNeuro · 2023Article
- Maternal separation modifies spontaneous synaptic activity in the infralimbic cortex of stress-resilient male rats.PloS one · 2023Article
- A feedforward inhibitory premotor circuit for auditory-vocal interactions in zebra finches.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- DARPP-32 distinguishes a subset of adult-born neurons in zebra finch HVC.The Journal of comparative neurology · 2022Article
- Intrinsic plasticity and birdsong learning.Neurobiology of learning and memory · 2021Review
- Addition of new neurons and the emergence of a local neural circuit for precise timing.PLoS computational biology · 2021Article
- Molecular specializations of deep cortical layer analogs in songbirds.Scientific reports · 2020Article
- Experience- and Sex-Dependent Intrinsic Plasticity in the Zebra Finch Auditory Cortex during Song Memorization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spiking and Membrane Properties of Rat Olfactory Bulb Dopamine Neurons.Frontiers in cellular neuroscience · 2020Article
- Exploring the molecular basis of neuronal excitability in a vocal learner.BMC genomics · 2019Article
- Experience-Dependent Intrinsic Plasticity During Auditory Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Juvenile male zebra finches learn their songs over distinct auditory and sensorimotor stages, the former requiring exposure to an adult tutor song pattern. The cortical premotor nucleus HVC (acronym is name) plays a necessary role in both learning stages, as well as the production of adult song. Consistent with neural network models where synaptic plasticity mediates developmental forms of learning, exposure to tutor song drives changes in the turnover, density, and morphology of HVC synapses during vocal development. A network's output, however, is also influenced by the intrinsic properties (e.g., ion channels) of the component neurons, which could change over development. Here, we use patch clamp recordings to show cell-type-specific changes in the intrinsic physiology of HVC projection neurons as a function of vocal development. Developmental changes in HVC neurons that project to the basal ganglia include an increased voltage sag response to hyperpolarizing currents and an increased rebound depolarization following hyperpolarization. Developmental changes in HVC neurons that project to vocal-motor cortex include a decreased resting membrane potential and an increased spike amplitude. HVC interneurons, however, show a relatively stable range of intrinsic features across vocal development. We used mathematical models to deduce possible changes in ionic currents that underlie the physiological changes and to show that the magnitude of the observed changes could alter HVC circuit function. The results demonstrate developmental plasticity in the intrinsic physiology of HVC projection neurons and suggest that intrinsic plasticity may have a role in the process of song learning.
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