Evidence map›Paper›PMID 29062593›Full record

ArticleFatigue : biomedicine, health & behavior2017

Clinical Criteria Versus a Possible Research Case Definition in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Leonard A Jason, Stephanie McManimen, Madison Sunnquist, Julia L Newton, Elin Bolle Strand

Abstract read
In one paragraph

Article in Fatigue : biomedicine, health & behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
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  8. A Brief Questionnaire to Assess Post-Exertional Malaise.Diagnostics (Basel, Switzerland) · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leonard A JasonDePaul University.
Stephanie McManimenDePaul University.
Madison SunnquistDePaul University.
Julia L NewtonInstitute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
Elin Bolle StrandOslo University Hospital, Oslo, Norway.

Funding

A prospective study of CFS following infectious mononucleosis in college studentsR01AI105781 · NIAID · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI JASON, LEONARD A, KATZ, BEN Z. · 2014 to 2018
$3.4M
Pediatric CFS in a Community-Based SampleR01HD072208 · NICHD · DE PAUL UNIVERSITY · PI JASON, LEONARD A · 2013 to 2017
$2.0M
NIAID NIH HHS R01 AI105781NICHD NIH HHS R01 HD072208
6 · The paper itself

Abstract

backgroundThe Institute of Medicine (IOM) recently developed clinical criteria for what had been known as chronic fatigue syndrome (CFS). Given the broad nature of the clinical IOM criteria, there is a need for a research definition that would select a more homogenous and impaired group of patients than the IOM clinical criteria. At the present time, it is unclear what will serve as the research definition. PURPOSE: The current study focused on a research definition which selected homebound individuals who met the four IOM criteria, excluding medical and psychiatric co-morbidities.

methodsOur research criteria were compared to those participants meeting the IOM criteria. Those not meeting either of these criteria sets were placed in a separate group defined by 6 or more months of fatigue. Data analyzed were from the DePaul Symptom Questionnaire and the SF-36. Due to unequal sample sizes and variances, Welch's

resultsUsing a large database of over 1,000 patients from several countries, we found that those meeting a more restrictive research definition were even more impaired and more symptomatic than those meeting criteria for the other two groups.

conclusionDeciding on a particular research case definition would allow researchers to select more comparable patient samples across settings, and this would represent one of the most significant methodologic advances for this field of study.

Indexed as

case definitionschronic fatigue syndromemyalgic encephalomyelitis

Identifiers

PMID29062593
PMCPMC5650200

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.