ArticleNeural plasticity2017
Does the Somatosensory Temporal Discrimination Threshold Change over Time in Focal Dystonia?
Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Temporal discrimination at the neck region is associated with severity of cervical dystonia.Scientific reports · 2025Article
- Do Hormonal Fluctuations in Healthy Women Influence the Somatosensory Temporal Discrimination Threshold?Brain and behavior · 2025Article
- Elucidation of the mechanism underlying impaired sensorimotor gating in patients with primary blepharospasm using prepulse inhibition.Frontiers in neurology · 2023Article
- Are Neurophysiological Biomarkers Able to Discriminate Multiple Sclerosis Clinical Subtypes?Biomedicines · 2022Article
- Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence.F1000Research · 2020Review
- The role of sensory information in the pathophysiology of focal dystonias.Nature reviews. Neurology · 2019Review
- Actual and Illusory Perception in Parkinson's Disease and Dystonia: A Narrative Review.Frontiers in neurology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe somatosensory temporal discrimination threshold (STDT) is defined as the shortest interval at which an individual recognizes two stimuli as asynchronous. Some evidence suggests that STDT depends on cortical inhibitory interneurons in the basal ganglia and in primary somatosensory cortex. Several studies have reported that the STDT in patients with dystonia is abnormal. No longitudinal studies have yet investigated whether STDT values in different forms of focal dystonia change during the course of the disease.
methodsWe designed a follow-up study on 25 patients with dystonia (15 with blepharospasm and 10 with cervical dystonia) who were tested twice: upon enrolment and 8 years later. STDT values from dystonic patients at the baseline were also compared with those from a group of 30 age-matched healthy subjects.
resultsOur findings show that the abnormally high STDT values observed in patients with focal dystonia remained unchanged at the 8-year follow-up assessment whereas disease severity worsened.
conclusionsOur observation that STDT abnormalities in dystonia remain unmodified during the course of the disease suggests that the altered activity of inhibitory interneurons-either at cortical or at subcortical level-responsible for the increased STDT does not deteriorate as the disease progresses.
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