ArticleJournal of advanced research2017
Increased susceptibility of post-weaning rats on high-fat diet to metabolic syndrome.
Article in Journal of advanced research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Adult mice are more susceptible to high-fat diet-induced visceral adiposity and insulin resistance than juvenile mice.Journal of endocrinological investigation · 2026Article
- Effect of post-weaning diet on hibernation occurrence in Syrian hamsters.Experimental animals · 2026Article
- Repeatability and Variability of a High-Fat High-Fructose Diet-Induced Metabolic Syndrome Model in Young Adult Male Wistar Rats.Methods and protocols · 2026Article
- Tridiet-enhanced weight gain in Sprague Dawley rats: a retrospective analysis.Frontiers in nutrition · 2026Article
- Article
- Experimental Models of Type 2 Diabetes Mellitus Induced by Combining Hyperlipidemic Diet (HFD) and Streptozotocin Administration in Rats: An Integrative Review.Biomedicines · 2025Review
- Microbiota-Based Intervention Alleviates High-Fat Diet Consequences Through Host-Microbe Environment Remodeling.Nutrients · 2025Review
- Article
- Efficacy of Fetal Wharton's Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome.Biomolecules · 2025Article
- Article
- Protective Effect of Tertiary Butylhydroquinone against Obesity-induced Skeletal Muscle Pathology in Post-weaning High Fat Diet Fed Rats.Current pharmaceutical biotechnology · 2024Article
- Geraniin Ameliorates Hypertensive Vascular Remodelling in a Diet-Induced Obese Animal Model through Antioxidant and Anti-Inflammatory Effects.Nutrients · 2023Article
- Effect of Agave Fructan Bioconjugates on Metabolic Syndrome Parameters in a Murine Model.Pharmaceuticals (Basel, Switzerland) · 2023Article
- Effects of different diets used to induce obesity/metabolic syndrome on bladder function in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers: Evidence from High-Fat Diet Model in Wistar Rats.Antioxidants (Basel, Switzerland) · 2022Article
- Proposal of a Mathematical Model to Monitor Body Mass over Time in Subjects on a Diet.Nutrients · 2022Article
- Chronic chemogenetic manipulation of ventral pallidum targeted neurons in male rats fed an obesogenic diet.Brain research · 2022Article
- Intake of slow-digesting carbohydrates is related to changes in the microbiome and its functional pathways in growing rats with obesity induced by diet.Frontiers in nutrition · 2022Article
- Metabolic Syndrome: Lessons from Rodent andBioMed research international · 2022Review
- Quality More Than Quantity: The Use of Carbohydrates in High-Fat Diets to Tackle Obesity in Growing Rats.Frontiers in nutrition · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to examine the effects of the types of high-calorie diets (high-fat and high-fat-high-sucrose diets) and two different developmental stages (post-weaning and young adult) on the induction of metabolic syndrome. Male, post-weaning and adult (3- and 8-week old, respectively) Sprague Dawley rats were given control, high-fat (60% kcal), and high-fat-high-sucrose (60% kcal fat + 30% sucrose water) diets for eight weeks (n = 6 to 7 per group). Physical, biochemical, and transcriptional changes as well as liver histology were noted. Post-weaning rats had higher weight gain, abdominal fat mass, fasting glucose, high density lipoprotein cholesterol, faster hypertension onset, but lower circulating advanced glycation end products compared to adult rats. This is accompanied by upregulation of peroxisome proliferator-activated receptor (PPAR) α and γ in the liver and receptor for advanced glycation end products (RAGE) in the visceral adipose tissue. Post-weaning rats on high-fat diet manifested all phenotypes of metabolic syndrome and increased hepatic steatosis, which are linked to increased hepatic and adipocyte PPARγ expression. Adult rats on high-fat-high-sucrose diet merely became obese and hypertensive within the same treatment duration. Thus, it is more effective and less time-consuming to induce metabolic syndrome in male post-weaning rats with high-fat diet compared to young adult rats. As male rats were selectively included into the study, the results may not be generalisable to all post-weaning rats and further investigation on female rats is required.
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