Evidence map›Paper›PMID 29062463›Full record

ArticleOxidative medicine and cellular longevity2017

Antioxidant Treatment Reduces Formation of Structural Cores and Improves Muscle Function in RYR1

Antonio Michelucci, Alessandro De Marco, Flavia A Guarnier, Feliciano Protasi, Simona Boncompagni

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Biomolecules · 2025
    Article
  3. NADSkeletal muscle · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Ablation of Calsequestrin-1, CaFrontiers in physiology · 2022
    Review
  11. Article
  12. Altered CaMetabolites · 2021
    Review
  13. Calsequestrin, a key protein in striated muscle health and disease.Journal of muscle research and cell motility · 2021
    Review
  14. Review
  15. Early Findings in Neonatal Cases ofFrontiers in neurology · 2021
    Article
  16. Bioenergetic defects in muscle fibers ofThe Journal of biological chemistry · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Antonio MichelucciCenter for Research on Aging and Translational Medicine (CeSI-MeT), University G. d'Annunzio of Chieti, 66100 Chieti, Italy.
Alessandro De MarcoCenter for Research on Aging and Translational Medicine (CeSI-MeT), University G. d'Annunzio of Chieti, 66100 Chieti, Italy.
Flavia A GuarnierDepartment of General Pathology, University Estadual de Londrina, 86057-970 Londrina, PR, Brazil.
Feliciano ProtasiCenter for Research on Aging and Translational Medicine (CeSI-MeT), University G. d'Annunzio of Chieti, 66100 Chieti, Italy.ORCID 0000-0002-0213-7591
Simona BoncompagniCenter for Research on Aging and Translational Medicine (CeSI-MeT), University G. d'Annunzio of Chieti, 66100 Chieti, Italy.ORCID 0000-0001-5308-5069
University of Chieti-Pescara · ITUniversidade Estadual de Londrina · BR

Funding

Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core DiseaseR01AR053349 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DIRKSEN, ROBERT T, HAMILTON, SUSAN L · 2006 to 2020
$8.0M
NIAMS NIH HHS R01 AR053349
6 · The paper itself

Abstract

Central core disease (CCD) is a congenital myopathy linked to mutations in the ryanodine receptor type 1 (RYR1), the sarcoplasmic reticulum Ca

Indexed as

AnimalsAntioxidantsHumansMiceMuscle, SkeletalMyopathy, Central CoreRyanodine Receptor Calcium Release ChannelAntioxidantsRyanodine Receptor Calcium Release Channel

Identifiers

PMID29062463
PMCPMC5610828
OpenAlexW2753145576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.