ArticleFrontiers in immunology2017
Preterm Birth Affects the Risk of Developing Immune-Mediated Diseases.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Child characteristics, household, and home environmental factors associated with eczema: a cross-sectional study.European journal of pediatrics · 2026Article
- Immunization Status and Effectiveness Analysis of Hepatitis B Vaccine Among Preterm Infants in Fujian Province, 2022-2023.Vaccines · 2026Article
- Reconceptualizing chorioamnionitis as an immune-mediated inflammatory disorder at the maternal-fetal interface.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Perturbation of the preterm human immune system in early life.JCI insight · 2026Article
- Radar-Based Monitoring: A Proof of Principle Study in a Piglet Model for a Novel Approach in Non-Contact Vital Sign Monitoring.Sensors (Basel, Switzerland) · 2026Article
- Comparison of Serum TARC Levels at Term-Equivalent Age Between Preterm and Term Infants.Journal of immunology research · 2026Article
- Newborn Transepidermal Water Loss and Gestational Age as Predictive Factors for Infant Atopic Dermatitis in the First Three Months of Age.Allergy, asthma & immunology research · 2026Article
- Atopic diseases in pediatric population: prematurity and small for gestational age.BMC pediatrics · 2025Article
- Perturbation of the Preterm Human Immune System in Early Life.medRxiv : the preprint server for health sciences · 2025Article
- Association between preterm birth and asthma and atopic dermatitis in preschool children: a nationwide population-based study.European journal of pediatrics · 2024Article
- Investigation of a Camera-Based Contactless Pulse Oximeter with Time-Division Multiplex Illumination Applied on Piglets for Neonatological Applications.Biosensors · 2024Article
- [Pregnant women with COVID-19 ARDS on the intensive care unit].Die Anaesthesiologie · 2024Article
- Article
- Antibody deficiencies in children are associated with prematurity and a family history of infections.Pediatric research · 2023Article
- Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth.Croatian medical journal · 2023Article
- Atopic dermatitis and gestational age - is there an association between them? A review of the literature and an analysis of pathology.Postepy dermatologii i alergologii · 2023Review
- Prevalence of asthma in preterm and associated risk factors based on prescription data from the Korean National Health Insurance database.Scientific reports · 2023Article
- Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm.Chemosphere · 2023Article
- Monocyte signature as a predictor of chronic lung disease in the preterm infant.Frontiers in immunology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prematurity affects approximately 10% of all children, resulting in drastically altered antigen exposure due to premature confrontation with microbes, nutritional antigens, and other environmental factors. During the last trimester of pregnancy, the fetal immune system adapts to tolerate maternal and self-antigens, while also preparing for postnatal immune defense by acquiring passive immunity from the mother. Since the perinatal period is regarded as the most important "window of opportunity" for imprinting metabolism and immunity, preterm birth may have long-term consequences for the development of immune-mediated diseases. Intriguingly, preterm neonates appear to develop bronchial asthma more frequently, but atopic dermatitis less frequently in comparison to term neonates. The longitudinal study of preterm neonates could offer important insights into the process of imprinting for immune-mediated diseases. On the one hand, preterm birth may interrupt influences of the intrauterine environment on the fetus that increase or decrease the risk of later immune disease (e.g., maternal antibodies and placenta-derived factors), whereas on the other hand, it may lead to the premature exposure to protective or harmful extrauterine factors such as microbiota and nutritional antigen. Solving this puzzle may help unravel new preventive and therapeutic approaches for immune diseases.
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