Evidence map›Paper›PMID 29062309›Full record

ArticleFrontiers in microbiology2017

pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal Pathogen

Julien Chaillot, Faiza Tebbji, Carlos García, Hugo Wurtele, René Pelletier, Adnane Sellam

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A comprehensive review on pharmacological applications and drug-induced toxicity of valproic acid.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  7. Antifungal Activity of Bulgarian Rose Damascena Oil against Vaginitis-Causing Opportunistic Fungi.Evidence-based complementary and alternative medicine : eCAM · 2023
    Article
  8. Article
  9. Article
  10. Chromatin Structure and Drug Resistance inJournal of fungi (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julien ChaillotInfectious Diseases Research Centre-CRI, Research Center of the CHU de Québec, Université Laval, Quebec, QC, Canada.
Faiza TebbjiInfectious Diseases Research Centre-CRI, Research Center of the CHU de Québec, Université Laval, Quebec, QC, Canada.
Carlos GarcíaInfectious Diseases Research Centre-CRI, Research Center of the CHU de Québec, Université Laval, Quebec, QC, Canada.
Hugo WurteleMaisonneuve-Rosemont Hospital Research Center, Montreal, QC, Canada.
René PelletierMedical Microbiology and Infectious Diseases, Research Center of the CHU de Québec, Quebec, QC, Canada.
Adnane SellamInfectious Diseases Research Centre-CRI, Research Center of the CHU de Québec, Université Laval, Quebec, QC, Canada.
Université Laval · CACentre hospitalier universitaire de Québec · CAHôpital Maisonneuve-Rosemont · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VPA) exhibited a strong antifungal activity against both sensitive and resistant

Indexed as

antifungalCandida albicansvacuolevalproic acidvulvovaginal candidiasis

Identifiers

PMID29062309
PMCPMC5640775
OpenAlexW2757849159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.