ArticleInternational journal of chronic obstructive pulmonary disease2017
Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medication burden in patients with dialysis-dependent CKD: a systematic review.Renal failure · 2024Pooled it
- Polypharmacy Increases Risk of Dyspnea Among Adults With Serious, Life-Limiting Diseases.The American journal of hospice & palliative care · 2020Trial
- Polypharmacy and Drug-Drug Interactions in Chronic Obstructive Pulmonary Disease: A Narrative Clinical Review.Pharmaceutics · 2026Review
- Disease Onset and Burden in Patients With Chronic Bronchitis and COPD: A Real-World Evidence Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Preclinical Identification of Poorly Controlled COPD: Patients with a Single Moderate Exacerbation Matter Too.Journal of clinical medicine · 2024Article
- Associations between Diabetes-Specific Medication Regimen Complexity and Cardiometabolic Outcomes among Underserved Non-Hispanic Black Adults Living with Type 2 Diabetes Mellitus.Pharmacy (Basel, Switzerland) · 2024Article
- Association between medication complexity and follow-up care attendance: insights from a retrospective multicenter cohort study across 1,223 Chinese hospitals.Frontiers in pharmacology · 2024Article
- Article
- Workup of difficult-to-treat asthma: implications from treatable traits.Precision clinical medicine · 2023Article
- Assessment of Medication Regimen Complexity of COPD Regimens in Individuals Visiting Community Pharmacies.International journal of chronic obstructive pulmonary disease · 2023Article
- Comparing and validating medication complexity from insurance claims against electronic health records.Journal of managed care & specialty pharmacy · 2022Article
- Treatment Burden Discussion in Clinical Encounters: Priorities of COPD Patients, Carers and Physicians.International journal of chronic obstructive pulmonary disease · 2022Article
- Associations of Medication Regimen Complexity with COPD Medication Adherence and Control.International journal of chronic obstructive pulmonary disease · 2021Article
- The inhibitor miR-21 regulates macrophage polarization in an experimental model of chronic obstructive pulmonary disease.Tobacco induced diseases · 2021Article
- A Real-World Analysis of Treatment Patterns and Clinical Characteristics Among Patients with COPD Who Initiated Multiple-Inhaler Triple Therapy in New Zealand.International journal of chronic obstructive pulmonary disease · 2021Article
- Association of treatments for acute myocardial infarction and survival for seven common comorbidity states: a nationwide cohort study.BMC medicine · 2020Article
- Community-acquired and hospital-acquired medication harm among older inpatients and impact of a state-wide medication management intervention.BMJ quality & safety · 2019Article
- A non-randomised controlled pilot study of clinical pharmacist collaborative intervention for community dwelling patients with COPD.NPJ primary care respiratory medicine · 2018Article
- The association between polypharmacy and medication regimen complexity and antibiotic use in bronchiectasis.International journal of clinical pharmacy · 2018Article
- Associations of medication regimen complexity with medication adherence and clinical outcomes in patients with chronic obstructive pulmonary disease: a prospective study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCOPD patients are often prescribed multiple medications for their respiratory disease and comorbidities. This can lead to complex medication regimens resulting in poor adherence, medication errors, and drug-drug interactions. The relationship between clinical outcomes and medication burden beyond medication count in COPD is largely unknown.
objectivesThe aim of this study was to explore the relationships of medication burden in COPD with clinical outcomes, comorbidities, and multidimensional indices.
methodsIn a cross-sectional study, COPD patients (n=222) were assessed for demographic information, comorbidities, medication use, and clinical outcomes. Complexity of medication regimens was quantified using the validated medication regimen complexity index (MRCI).
resultsParticipants (58.6% males) had a mean (SD) age of 69.1 (8.3) years with a postbronchodilator forced expiratory volume in 1 second % predicted of 56.5 (20.4) and a median of five comorbidities. The median (
conclusionIn COPD patients, complex medication regimens are associated with disease severity and specific class of comorbidities.
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