ArticleScientific reports2017
Toxoplasma-induced changes in host risk behaviour are independent of parasite-derived AaaH2 tyrosine hydroxylase.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effects of Toxoplasma Gondii Type II Infection on Serum Serotonin Concentration and Indoleamine 2,3-Dioxygenase Gene Expression in Balb/c Mice.Acta parasitologica · 2026Article
- Article
- The role of parasite-produced dopamine in Toxoplasma gondii-altered host behaviour.Nature communications · 2025Article
- 4-Arylthiosemicarbazide Derivatives as Toxoplasmic Aromatic Amino Acid Hydroxylase Inhibitors and Anti-inflammatory Agents.International journal of molecular sciences · 2022Article
- Toxoplasmosis and Schizophrenia: A Systematic Review and Meta-Analysis of Prevalence and Associations and Future Directions.Psychiatric research and clinical practice · 2022Article
- Epigenetic Manipulation of Psychiatric Behavioral Disorders Induced byFrontiers in cellular and infection microbiology · 2022Review
- Article
- Functional Characterization of the Thrombospondin-Related Paralogous Proteins Rhoptry Discharge Factors 1 and 2 Unveils Phenotypic Plasticity inFrontiers in microbiology · 2022Article
- 4-Arylthiosemicarbazide derivatives as a new class of tyrosinase inhibitors and anti-Journal of enzyme inhibition and medicinal chemistry · 2021Article
- Evaluation of the Tyrosine and Dopamine Serum Levels in Experimental Infected BALB/c Mice with Chronic Toxoplasmosis.Journal of parasitology research · 2021Article
- When fiction becomes fact: exaggerating host manipulation by parasites.Proceedings. Biological sciences · 2020Article
- A Review on the Prevalence ofInternational journal of environmental research and public health · 2020Review
- Latent Toxoplasmosis Effects on Rodents and Humans: How Much is Real and How Much is Media Hype?mBio · 2020Review
- Article
- Toxoplasma gondii infection damages the perineuronal nets in a murine model.Memorias do Instituto Oswaldo Cruz · 2020Article
- Article
- Efficient genome engineering of Toxoplasma gondii using the TALEN technique.Parasites & vectors · 2019Article
- Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia.Schizophrenia bulletin · 2018Review
- AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse.Behavioural brain research · 2018Article
- Mind Control: How Parasites Manipulate Cognitive Functions in Their Insect Hosts.Frontiers in psychology · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Toxoplasma gondii infects a broad range of hosts and can establish chronic infections with the formation of brain cysts. Infected animals show altered risk behaviour which has been suggested to increase capture probability of hosts, and thus enhance parasite transmission. It has been proposed that the ability of Toxoplasma cysts to secrete tyrosine hydroxylase could mediate these behavioural alterations. We tested the involvement of secreted tyrosine hydroxylase, coded by the parasite AaaH2 gene, in the development of alterations in mouse behaviour, by generating an AaaH2 deletion mutant parasite strain and testing its influence on behaviour. We found that both mice infected with wild type or AaaH2 mutant strains showed changes in risk behaviour. We confirmed these findings using factor analysis of the behaviour, which revealed that behavioural changes happened along a single dimension, and were observed in both infected groups. Furthermore, we developed a new behavioural paradigm in which animals are unpredictably trapped, and observed that both groups of infected animals perceive trapping but fail to adjust their behaviour to avoid further trapping. These results demonstrate that parasite-secreted AaaH2 TH is neither necessary for the generation of risky behaviour nor for the increased trappability observed during chronic Toxoplasma infection.
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