Evidence map›Paper›PMID 29062072›Full record

ReviewNature reviews. Microbiology2018

Development and regulation of single- and multi-species Candida albicans biofilms.

Matthew B Lohse, Megha Gulati, Alexander D Johnson, Clarissa J Nobile

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 332 papers.

0numbers the graph read from it
0cells of the map it votes in
332citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

332 citing papers in PubMed.

  1. Article
  2. Microorganisms · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Voriconazole Activity AgainstMolecules (Basel, Switzerland) · 2026
    Article
  11. Article
  12. Article
  13. Disruption of thePathogens (Basel, Switzerland) · 2026
    Article
  14. Article
  15. Copper-driven mutualism ofMicrobiology (Reading, England) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Roles of Indole and Its Derivative in ModulatingInternational journal of molecular sciences · 2026
    Article

272 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew B LohseDepartment of Microbiology and Immunology, University of California, San Francisco (UCSF), 600 16th Street, San Francisco, California 94158, USA.
Megha GulatiDepartment of Molecular and Cell Biology, University of California, Merced (UC Merced), 5200 North Lake Road, Merced, California 95343, USA.
Alexander D JohnsonDepartment of Microbiology and Immunology, University of California, San Francisco (UCSF), 600 16th Street, San Francisco, California 94158, USA.
Clarissa J NobileDepartment of Molecular and Cell Biology, University of California, Merced (UC Merced), 5200 North Lake Road, Merced, California 95343, USA.

Funding

The transcriptional circuitry controlling biofilm development in Candida albicansR01AI083311 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSON, ALEXANDER D · 2011 to 2020
$4.3M
Development of Therapeutics to Treat Candida albicans Biofilm InfectionsR41AI112038 · NIAID · BIOSYNESIS, INC. · PI NOBILE, CLARISSA JANE · 2015 to 2015
$225k
NIAID NIH HHS R01 AI083311NIAID NIH HHS R41 AI112038
6 · The paper itself

Abstract

Candida albicans is among the most prevalent fungal species of the human microbiota and asymptomatically colonizes healthy individuals. However, it is also an opportunistic pathogen that can cause severe, and often fatal, bloodstream infections. The medical impact of C. albicans typically depends on its ability to form biofilms, which are closely packed communities of cells that attach to surfaces, such as tissues and implanted medical devices. In this Review, we provide an overview of the processes involved in the formation of C. albicans biofilms and discuss the core transcriptional network that regulates biofilm development. We also consider some of the advantages that biofilms provide to C. albicans in comparison with planktonic growth and explore polymicrobial biofilms that are formed by C. albicans and certain bacterial species.

Indexed as

BiofilmsAntifungal AgentsCandida albicansDrug Resistance, FungalGene Expression Regulation, FungalGene Regulatory NetworksHumansAntifungal Agents

Identifiers

PMID29062072
PMCPMC5726514

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.